Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
coptisine | 53.85-61.54% inhibition at 0.075 mg/ml | Homo sapiens | |
coptisine | 85.86-86.87% inhibition at 0.05 mg/ml | Rattus norvegicus | |
epiberberine | 69.23-76.92% inhibition at 0.075 mg/ml | Homo sapiens | |
epiberberine | complete inhibition at 0.05 mg/ml | Rattus norvegicus | |
groenlandicine | 69.23-76.92% inhibition at 0.075 mg/ml | Homo sapiens | |
groenlandicine | 52.38-60.32% inhibition at 0.05 mg/ml | Rattus norvegicus | |
jateorrhizine | 12.68-14.08% inhibition at 0.05 mg/ml | Rattus norvegicus | |
magnoflorine | 18.33-29.85% inhibition at 0.05 mg/ml | Rattus norvegicus | |
additional information | berberine and palmatine exhibit no RLAR inhibitory activities within the test concentration of 0.012.5-0.05 mg/ml; extract and fractions of the rhizome of Coptis chinensis exhibit broad and moderate RLAR inhibitory activities of approximately 0.038.9-0.067.5 mg/ml | Rattus norvegicus | |
quercetin | - |
Homo sapiens | |
quercetin | 76.47-77.94% inhibition at 0.005 mg/ml | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lens | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
? | |
DL-glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus | glycerol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |
aldose reductase | - |
Rattus norvegicus |
HRAR | - |
Homo sapiens |
RLAR | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0188 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Rattus norvegicus | quercetin | |
0.1 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Rattus norvegicus | epiberberine | |
0.1184 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Rattus norvegicus | coptisine | |
0.1401 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Rattus norvegicus | groenlandicine | |
0.1542 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Homo sapiens | groenlandicine | |
0.1681 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Homo sapiens | epiberberine | |
0.1873 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Homo sapiens | coptisine |