Application | Comment | Organism |
---|---|---|
medicine | in streptozotocin-diabetic mice, aldose reductase inhibitor treatment or genetic deficiency of aldose reductase result in significant dephosphorylation of both peroxisome proliferator-activated receptor alpha and ERK1/2 | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression in AML12 cell | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | aldose reductase overexpression causes strong suppression of peroxisome proliferator-activated receptor alpha/delta activity together with significant down-regulation of mRNA expression for acetyl-CoA oxidase and carnitine palmitoyltransferase-1. Suppressive effects are attenuated by the selective aldose reductase inhibitor zopolrestat. Aldose reductase overexpression greatly increases the levels of phosphorylated peroxisome proliferator-activated receptor alpha and ERK1/2. Aldose reductase-induced suppression of peroxisome proliferator-activated receptor alpha activity is attenuated by treatment with an inhibitor for ERK1/2 but not that for phosphoinositide 3-kinase, p38, or JNK | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
zopolrestat | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | aldose reductase plays an important role in the regulation of hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity and lipid homeostasis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
AML-12 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | aldose reductase plays an important role in the regulation of hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity and lipid homeostasis | Mus musculus | ? | - |
? |