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Literature summary for 1.1.1.21 extracted from

  • Ramana, K.V.; Reddy, A.B.; Tammali, R.; Srivastava, S.K.
    Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages (2007), Free Radic. Biol. Med., 42, 1290-1302.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information inhibition or RNA interference ablation of aldose reductase suppresses lipopolysaccharide-stimulated production of nitric oxide and over-expression of inducible nitric oxide synthase. Inhibition also prevents the lipopolysaccaride-induced apoptosis, cell cycle arrest, activation of caspase-3, downregulation of Bcl-xl and up-regulation of Bax and Bak in macrophages Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
sorbinil inhibition of aldose reductase suppresses lipopolysaccharide-stimulated production of nitric oxide and over-expression of inducible nitric oxide synthase. Inhibition also prevents the lipopolysaccaride-induced apoptosis, cell cycle arrest, activation of caspase-3, downregulation of Bcl-xl and up-regulation of Bax and Bak in macrophages Mus musculus
Tolrestat inhibition of aldose reductase suppresses lipopolysaccharide-stimulated production of nitric oxide and over-expression of inducible nitric oxide synthase. Inhibition also prevents the lipopolysaccaride-induced apoptosis, cell cycle arrest, activation of caspase-3, downregulation of Bcl-xl and up-regulation of Bax and Bak in macrophages Mus musculus
zopolrestat inhibition of aldose reductase suppresses lipopolysaccharide-stimulated production of nitric oxide and over-expression of inducible nitric oxide synthase. Inhibition also prevents the lipopolysaccaride-induced apoptosis, cell cycle arrest, activation of caspase-3, downregulation of Bcl-xl and up-regulation of Bax and Bak in macrophages Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell inhibition or RNA interference ablation of aldose reductase suppresses lipopolysaccharide-stimulated production of nitric oxide and over-expression of inducible nitric oxide synthase. Inhibition also prevents the lipopolysaccaride-induced apoptosis, cell cycle arrest, activation of caspase-3, downregulation of Bcl-xl and up-regulation of Bax and Bak in macrophages Mus musculus
-