Literature summary for 1.1.1.21 extracted from

Biadene, M.; Hazemann, I.; Cousido, A.; Ginell, S.; Joachimiak, A.; Sheldrick, G.M.; Podjarny, A.; Schneider, T.R.
The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop (2007), Acta Crystallogr. Sect. D, 63, 665-672.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with citrate and inhibitor fidarestat, resolution of 0.82 A. After the catalytic event, a rearrangement of a bound ligand can trigger the opening of the safety-belt loop of G213-S226, initiating the release of the oxidized cofactor	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
fidarestat	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15121	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
alditol + NAD(P)+ = aldose + NAD(P)H + H+	after the catalytic event, a rearrangement of a bound ligand can trigger the opening of the safety-belt loop of G213-S226, initiating the release of the oxidized cofactor	Homo sapiens	a

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Homo sapiens
NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)