Cloned (Comment) | Organism |
---|---|
transgenic C57BL6 background mice overexpressing human aldose reductase exhibit increased JAK2 and STAT5 activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of AR protects the ischemic myocardium and is associated with improved energy metabolism | Homo sapiens | |
additional information | inhibition of AR protects the ischemic myocardium and is associated with improved energy metabolism | Rattus norvegicus | |
zopolrestat | - |
Homo sapiens | |
zopolrestat | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + NADPH + H+ | Homo sapiens | the aldose reductase pathway has been demonstrated to be a key component of myocardial ischemia reperfusion injury, inhibition of AR protects the ischemic myocardium and is associated with improved energy metabolism, overview, pharmacological inhibition of the enzyme or sorbitol dehydrogenase blocks JAK2 and STAT5 activation and is associated with lower lactate/pyruvate ratio and lower protein kinase C activity, mechanism, overview | sorbitol + NADP+ | - |
? | |
D-glucose + NADPH + H+ | Rattus norvegicus | the aldose reductase pathway has been demonstrated to be a key component of myocardial ischemia reperfusion injury, inhibition of AR protects the ischemic myocardium and is associated with improved energy metabolism, overview, pharmacological inhibition of the enzyme or sorbitol dehydrogenase blocks JAK2 and STAT5 activation and is associated with lower lactate/pyruvate ratio and lower protein kinase C activity, mechanism, overview | sorbitol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
heart | - |
Rattus norvegicus | - |
myocardium | - |
Homo sapiens | - |
myocardium | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + NADPH + H+ | - |
Homo sapiens | sorbitol + NADP+ | - |
? | |
D-glucose + NADPH + H+ | - |
Rattus norvegicus | sorbitol + NADP+ | - |
? | |
D-glucose + NADPH + H+ | the aldose reductase pathway has been demonstrated to be a key component of myocardial ischemia reperfusion injury, inhibition of AR protects the ischemic myocardium and is associated with improved energy metabolism, overview, pharmacological inhibition of the enzyme or sorbitol dehydrogenase blocks JAK2 and STAT5 activation and is associated with lower lactate/pyruvate ratio and lower protein kinase C activity, mechanism, overview | Homo sapiens | sorbitol + NADP+ | - |
? | |
D-glucose + NADPH + H+ | the aldose reductase pathway has been demonstrated to be a key component of myocardial ischemia reperfusion injury, inhibition of AR protects the ischemic myocardium and is associated with improved energy metabolism, overview, pharmacological inhibition of the enzyme or sorbitol dehydrogenase blocks JAK2 and STAT5 activation and is associated with lower lactate/pyruvate ratio and lower protein kinase C activity, mechanism, overview | Rattus norvegicus | sorbitol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |
aldose reductase | - |
Rattus norvegicus |
ARI | - |
Homo sapiens |
ARI | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |