Literature summary for 1.1.1.21 extracted from

Doorn, J.A.; Srivastava, S.K.; Petersen, D.R.
Aldose reductase catalyzes reduction of the lipid peroxidation product 4-oxonon-2-enal (2003), Chem. Res. Toxicol., 16, 1418-1423.

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Activating Compound

Activating Compound	Comment	Organism	Structure
NADPH	in absence, loss of 60% of activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15121	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-hydroxynonen-4-one + NADPH	-	Homo sapiens	1,4-dihydroxynon-2-ene + NADP+	-	?
4-oxonon-2-enal + NADPH + H+	-	Homo sapiens	1-hydroxynonen-4-one + NADP+	-	?
glutathione-S-4-oxonon-2-enal + NADPH	-	Homo sapiens	S-(1-hydroxy-4-oxonona-3-yl)glutathione + NADP+	-	?
additional information	reduction occurs first at aldehyde group and then at ketone site	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)