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Literature summary for 1.1.1.21 extracted from

  • Nishimura, C.; Yamaoka, T.; Mizutani, M.; Yamashita, K.; Akera, T.; Tanimoto, T.
    Purification and characterization of the recombinant human aldose reductase expressed in baculovirus system (1991), Biochim. Biophys. Acta, 1078, 171-178.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in baculovirus system Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(E,E)-5[2-methyl-3-phenyl-2-propenylidene-4-oxo-2-thioxo-3-thiazolidine]acetic acid recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
(S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
N-[[6-methoxy-5(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
NADPH recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
0.018
-
L-glyceraldehyde recombinant from baculovirus system with Spodoptera frugiperda cells Homo sapiens
3.53
-
D-glucuronate recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
5.04
-
D-xylose recombinant fron baculovirus system in Spodoptera frugiperda cells Homo sapiens
43.3
-
D-galactose recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
98.1
-
D-glucose recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
? * 36000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
expressed in baculovirus system Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Homo sapiens
-
retina
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alditol + NAD(P)+
-
Homo sapiens aldose + NAD(P)H
-
r
aldose + NAD(P)H
-
Homo sapiens alditol + NAD(P)+
-
r
D-galactose + NAD(P)H
-
Homo sapiens dulcitol + NAD(P)+
-
r
D-glucose + NAD(P)H
-
Homo sapiens sorbitol + NAD(P)+
-
r
D-glucuronate + NAD(P)H
-
Homo sapiens ?
-
r
D-xylose + NAD(P)H
-
Homo sapiens xylitol + NAD(P)+
-
r
DL-glyceraldehyde + NAD(P)H
-
Homo sapiens glycerol + NAD(P)+
-
r
L-glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
r

Subunits

Subunits Comment Organism
More ? * 36000, SDS-PAGE Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.418
-
D-glucuronate recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
0.48
-
D-glucose recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
0.525
-
D-galactose recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
0.635
-
D-xylose recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens
0.673
-
DL-glyceraldehyde recombinant from baculovirus system in Spodoptera frugiperda cells Homo sapiens