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Literature summary for 1.1.1.21 extracted from

  • Sato, S.; Old, S.; Carper, D.; Kador, P.F.
    Purification and characterization of recombinant human placental and rat lens aldose reductases expressed in Escherichia coli (1995), Adv. Exp. Med. Biol., 5, 259-268.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
(NH4)2SO4 0.1 M Homo sapiens
(NH4)2SO4 0.1 M Rattus norvegicus
(NH4)2SO4 wild type and recombinant from Escherichia coli Homo sapiens
(NH4)2SO4 wild type and recombinant from Escherichia coli Rattus norvegicus
Na2SO4 0.1 M, wild type and recombinant from E.coli Homo sapiens
Na2SO4 0.1 M, wild type and recombinant from E.coli Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens
expression in Escherichia coli Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione wild type and recombinant from E. coli Homo sapiens
(S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione wild type and recombinant from E. coli Rattus norvegicus
Cl- 0.2 M, wild type and recombinant from E. coli Homo sapiens
Cl- 0.2 M, wild type and recombinant from E. coli Rattus norvegicus
N-[[6-methoxy-5(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine wild type and recombinant from E. coli Homo sapiens
N-[[6-methoxy-5(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine wild type and recombinant from E. coli Rattus norvegicus
ponalrestat wild type and recombinant from E. coli Homo sapiens
ponalrestat wild type and recombinant from E. coli Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.046
-
DL-glyceraldehyde
-
Homo sapiens
0.047
-
DL-glyceraldehyde recombinant from E. coli Homo sapiens
0.08
-
DL-glyceraldehyde
-
Rattus norvegicus
0.12
-
DL-glyceraldehyde recombinant from E. coli Rattus norvegicus
4.8
-
D-glucuronate
-
Homo sapiens
6.4
-
D-glucuronate recombinant from E. coli Homo sapiens
8.2
-
D-xylose
-
Homo sapiens
8.7
-
D-xylose recombinant from E. coli Homo sapiens
13.5
-
D-xylose
-
Rattus norvegicus
13.9
-
D-glucuronate recombinant from E. coli Rattus norvegicus
16.8
-
D-xylose recombinant from E. coli Rattus norvegicus
19.2
-
D-glucuronate
-
Rattus norvegicus
42.9
-
D-galactose recombinant from E. coli Homo sapiens
46.7
-
D-galactose
-
Homo sapiens
78
-
D-galactose recombinant from E. coli Rattus norvegicus
83
-
D-galactose
-
Rattus norvegicus
86.8
-
D-glucose
-
Homo sapiens
98.1
-
D-glucose recombinant from E. coli Homo sapiens
204
-
D-glucose
-
Rattus norvegicus
281
-
D-glucose recombinant from E. coli Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Li2SO4 0.1 M activation wild type and recombinant from E. coli Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
? * 38000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
wild type and expressed in Escherichia coli Homo sapiens
wild type and expressed in Escherichia coli Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
Homo sapiens
-
lens
-
Rattus norvegicus
-
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alditol + NAD(P)+
-
Homo sapiens aldose + NAD(P)H
-
r
alditol + NAD(P)+
-
Rattus norvegicus aldose + NAD(P)H
-
r
aldose + NAD(P)H
-
Homo sapiens alditol + NAD(P)+
-
r
aldose + NAD(P)H
-
Rattus norvegicus alditol + NAD(P)+
-
r
D-galactose + NAD(P)H
-
Homo sapiens dulcitol + NAD(P)+
-
r
D-galactose + NAD(P)H
-
Rattus norvegicus dulcitol + NAD(P)+
-
r
D-glucose + NAD(P)H
-
Homo sapiens sorbitol + NAD(P)+
-
r
D-glucose + NAD(P)H
-
Rattus norvegicus sorbitol + NAD(P)+
-
r
D-glucuronate + NAD(P)H
-
Homo sapiens ?
-
r
D-glucuronate + NAD(P)H
-
Rattus norvegicus ?
-
r
D-xylose + NAD(P)H
-
Homo sapiens xylitol + NAD(P)+
-
r
D-xylose + NAD(P)H
-
Rattus norvegicus xylitol + NAD(P)+
-
r
DL-glyceraldehyde + NAD(P)H
-
Homo sapiens glycerol + NAD(P)+
-
r
DL-glyceraldehyde + NAD(P)H
-
Rattus norvegicus glycerol + NAD(P)+
-
r

Subunits

Subunits Comment Organism
More ? * 38000, SDS-PAGE Homo sapiens