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Literature summary for 1.1.1.21 extracted from

  • Cromlish, J.A.; Flynn, T.G.
    Purification and characterization of two aldose reductase isoenzymes from rabbit muscle (1983), J. Biol. Chem., 258, 3416-3424.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
(NH4)2SO4 0.1 M Rattus norvegicus
(NH4)2SO4 400 mM: activation Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
(NH4)2SO4 0.05 mM: slight inhibition, 400 mM: activation Oryctolagus cuniculus
(S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione
-
Oryctolagus cuniculus
(S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione
-
Rattus norvegicus
Alrestatin 1,3-dioxo-1H-benz[de]isoquinoline-2-(3H)acetic acid Oryctolagus cuniculus
Cu2+
-
Oryctolagus cuniculus
HgCl2
-
Bos taurus
HgCl2
-
Oryctolagus cuniculus
p-chloromercuribenzoate
-
Oryctolagus cuniculus
p-chloromercuribenzoate
-
Rattus norvegicus
quercetin
-
Oryctolagus cuniculus
Zn2+
-
Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
gel filtration Oryctolagus cuniculus
40200
-
1 * 40200, aldose reductase 1, SDS-PAGE Oryctolagus cuniculus
41500
-
1 * 41500, aldose reductase 2, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Rattus norvegicus
-
alditol + NAD(P)+
-
r
aldose + NAD(P)H Sus scrofa
-
alditol + NAD(P)+
-
r
aldose + NAD(P)H Bos taurus
-
alditol + NAD(P)+
-
r
aldose + NAD(P)H Oryctolagus cuniculus
-
alditol + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
no glycoprotein
-
Rattus norvegicus
no glycoprotein
-
Sus scrofa
no glycoprotein
-
Bos taurus
no glycoprotein
-
Oryctolagus cuniculus

Purification (Commentary)

Purification (Comment) Organism
-
Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
Rattus norvegicus
-
lens
-
Sus scrofa
-
lens
-
Bos taurus
-
skeletal muscle
-
Rattus norvegicus
-
skeletal muscle
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrobenzaldehyde + NAD(P)H
-
Bos taurus 4-nitrobenzyl alcohol + NAD(P)+
-
?
4-nitrobenzaldehyde + NAD(P)H
-
Oryctolagus cuniculus 4-nitrobenzyl alcohol + NAD(P)+
-
?
alditol + NAD(P)+
-
Rattus norvegicus aldose + NAD(P)H
-
r
alditol + NAD(P)+
-
Sus scrofa aldose + NAD(P)H
-
r
alditol + NAD(P)+
-
Bos taurus aldose + NAD(P)H
-
r
alditol + NAD(P)+
-
Oryctolagus cuniculus aldose + NAD(P)H
-
r
aldose + NAD(P)H
-
Rattus norvegicus alditol + NAD(P)+
-
r
aldose + NAD(P)H
-
Sus scrofa alditol + NAD(P)+
-
r
aldose + NAD(P)H
-
Bos taurus alditol + NAD(P)+
-
r
aldose + NAD(P)H
-
Oryctolagus cuniculus alditol + NAD(P)+
-
r
D-glucose + NAD(P)H
-
Rattus norvegicus sorbitol + NAD(P)+
-
r
D-glucose + NAD(P)H
-
Bos taurus sorbitol + NAD(P)+
-
r
D-glucose + NAD(P)H
-
Oryctolagus cuniculus sorbitol + NAD(P)+
-
r
D-glucuronate + NAD(P)H
-
Rattus norvegicus ?
-
r
D-glucuronate + NAD(P)H
-
Bos taurus ?
-
r
D-glucuronate + NAD(P)H
-
Oryctolagus cuniculus ?
-
r
D-xylose + NAD(P)H
-
Rattus norvegicus xylitol + NAD(P)+
-
r
D-xylose + NAD(P)H
-
Bos taurus xylitol + NAD(P)+
-
r
D-xylose + NAD(P)H
-
Oryctolagus cuniculus xylitol + NAD(P)+
-
r
xylitol + NAD(P)+
-
Bos taurus D-xylose + NAD(P)H + H+
-
r
xylitol + NAD(P)+
-
Oryctolagus cuniculus D-xylose + NAD(P)H + H+
-
r

Subunits

Subunits Comment Organism
monomer
-
Rattus norvegicus
monomer 1 * 41500, aldose reductase 2, SDS-PAGE Bos taurus
monomer 1 * 40200, aldose reductase 1, SDS-PAGE Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7
-
Oryctolagus cuniculus