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Literature summary for 1.1.1.21 extracted from

  • Clements, R.S.; Winegrad, A.I.
    Purification of alditol: NADP oxidoreductase from human placenta (1972), Biochem. Biophys. Res. Commun., 47, 1473-1479.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
(NH4)2SO4 activation Homo sapiens
(NH4)2SO4 0.1 M Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3,3-Tetramethylene glutaric acid
-
Homo sapiens
3-hydroxybutyrate
-
Homo sapiens
3-hydroxybutyric acid
-
Homo sapiens
NaCl
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Li2SO4 stimulation Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39000
-
sucrose density gradient centrifugation, thin layer gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Homo sapiens
-
alditol + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.68
-
-
Homo sapiens

Storage Stability

Storage Stability Organism
4°C, 2 weeks in 1% ampholines Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alditol + NAD(P)+
-
Homo sapiens aldose + NAD(P)H
-
r
aldose + NAD(P)H
-
Homo sapiens alditol + NAD(P)+
-
r
D-erythrose + NAD(P)H
-
Homo sapiens erythritol + NAD(P)+
-
r
D-galactose + NAD(P)H
-
Homo sapiens dulcitol + NAD(P)+
-
r
D-glucose + NAD(P)H
-
Homo sapiens sorbitol + NAD(P)+
-
r
D-glucuronolactone + NADPH
-
Homo sapiens ?
-
?
D-ribose + NAD(P)H
-
Homo sapiens ribitol + NAD(P)+
-
r
D-xylose + NAD(P)H
-
Homo sapiens xylitol + NAD(P)+
-
r
L-arabinose + NAD(P)H
-
Homo sapiens L-arabitol + NAD(P)+
-
r
xylitol + NAD(P)+
-
Homo sapiens D-xylose + NAD(P)H + H+
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.8 6.7
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens