Application | Comment | Organism |
---|---|---|
drug development | 1,2,3-triazole IMPDH inhibitors provide new tools for elucidating the role of IMPDH in Cryptosporidium parvum and may serve as potential therapeutics for treating cryptosporidiosis | Cryptosporidium parvum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | 1,2,3-triazole containing ether IMPDH inhibitors, small alkyl group on the alpha-position of the ether is required, with the (R)-enantiomer significantly more active than the (S)-enantiomer. Electron-withdrawing groups in the 3- and/or 4-positions of the pendent phenyl ring are best, and conversion of the quinoline containing inhibitors to quinoline-N-oxides retains inhibitory activity both in the presence and absence of bovine serum albumin | Cryptosporidium parvum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptosporidium parvum | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
IMPDH | - |
Cryptosporidium parvum |
inosine 5'-monophosphate dehydrogenase | - |
Cryptosporidium parvum |