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Literature summary for 1.1.1.205 extracted from

  • Maurya, S.K.; Gollapalli, D.R.; Kirubakaran, S.; Zhang, M.; Johnson, C.R.; Benjamin, N.N.; Hedstrom, L.; Cuny, G.D.
    Triazole inhibitors of Cryptosporidium parvum inosine 5-monophosphate dehydrogenase (2009), J. Med. Chem., 52, 4623-4630.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development 1,2,3-triazole IMPDH inhibitors provide new tools for elucidating the role of IMPDH in Cryptosporidium parvum and may serve as potential therapeutics for treating cryptosporidiosis Cryptosporidium parvum

Inhibitors

Inhibitors Comment Organism Structure
additional information 1,2,3-triazole containing ether IMPDH inhibitors, small alkyl group on the alpha-position of the ether is required, with the (R)-enantiomer significantly more active than the (S)-enantiomer. Electron-withdrawing groups in the 3- and/or 4-positions of the pendent phenyl ring are best, and conversion of the quinoline containing inhibitors to quinoline-N-oxides retains inhibitory activity both in the presence and absence of bovine serum albumin Cryptosporidium parvum

Organism

Organism UniProt Comment Textmining
Cryptosporidium parvum
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-
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Synonyms

Synonyms Comment Organism
IMPDH
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Cryptosporidium parvum
inosine 5'-monophosphate dehydrogenase
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Cryptosporidium parvum