Application | Comment | Organism |
---|---|---|
drug development | at therapeutic concentrations in organ transplant patients, the effect of mycophenolic acid-acyl-glucuronide on IMPDHII activity is minimal compared to mycophenolic acid, and the quantification of mycophenolic acid metabolites for mycophenolate therapeutic drug monitoring and dose adjustment will be of no benefit | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | mycophenolic acid-phenyl-glucuronide has no effect | Homo sapiens | |
Mycophenolic acid | uncompetitive inhibition | Homo sapiens | |
mycophenolic acid-acyl-glucuronide | uncompetitive inhibition, is a weaker inhibitor of IMPDH II than mycophenolic acid. When coincubated with mycophenolic acid, mycophenolic acid-acyl-glucuronide activity is negligible at pharmacological concentrations | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00157 | - |
NAD+ | - |
Homo sapiens | |
0.00455 | - |
inosine 5'-phosphate | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | - |
Homo sapiens | xanthosine 5'-phosphate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IMPDH II | - |
Homo sapiens |
type 2 inosine monophosphate dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000508 | - |
Mycophenolic acid | in the presence of NAD+ | Homo sapiens | |
0.0000577 | - |
Mycophenolic acid | in the presence of inosine 5'-phosphate | Homo sapiens | |
0.000382 | - |
mycophenolic acid-acyl-glucuronide | in the presence of NAD+ | Homo sapiens | |
0.000511 | - |
mycophenolic acid-acyl-glucuronide | in the presence of inosine 5'-phosphate | Homo sapiens |