Application | Comment | Organism |
---|---|---|
drug development | IMPDH2 is the major target for cancer chemotherapy | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Cricetulus griseus |
- |
Escherichia coli |
- |
Pyrococcus horikoshii |
- |
Toxoplasma gondii |
- |
Streptococcus pyogenes |
- |
Pneumocystis carinii |
- |
Borreliella burgdorferi |
expressed in Escherichia coli | Homo sapiens |
expressed in Escherichia coli | Tritrichomonas suis |
expressed in Escherichia coli | Cryptosporidium parvum |
Crystallization (Comment) | Organism |
---|---|
tetramer structure of IMPDH shows square planar geometry | Streptococcus pyogenes |
Protein Variants | Comment | Organism |
---|---|---|
D226N | IMPDH1 polymorphism, which is associated with retinal degeneration | Homo sapiens |
D301N | IMPDH1 polymorphism, which does not affect protein function | Homo sapiens |
G324D | IMPDH1 polymorphism, which does not affect protein function | Homo sapiens |
G519R | IMPDH1 polymorphism, which does not affect protein function | Homo sapiens |
H296R | IMPDH1 polymorphism, which does not affect protein function | Homo sapiens |
H372P | IMPDH1 polymorphism, which is associated with retinal degeneration | Homo sapiens |
L263F | IMPDH2 polymorphism, which decreases the value of kcat by a factor of 10 | Homo sapiens |
N198K | IMPDH1 polymorphism, which is associated with retinal degeneration and with Leber congenital amaurosis | Homo sapiens |
R105W | IMPDH1 polymorphism, which is associated with retinal degeneration and with Leber congenital amaurosis | Homo sapiens |
R224P | IMPDH1 polymorphism, which is associated with retinal degeneration | Homo sapiens |
R231P | IMPDH1 polymorphism, which causes autosomal dominant retinitis pigmentosa | Homo sapiens |
T116M | IMPDH1 polymorphism, which is associated with retinal degeneration | Homo sapiens |
V268I | IMPDH1 polymorphism, which is associated with retinal degeneration | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-3-furan-2-yl-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]prop-2-enamide | - |
Homo sapiens | |
1,4-dimethyl-6-nitro-2H-cyclopenta[d]pyridazine | - |
Homo sapiens | |
1-(benzyloxy)-3-(3-pyridin-4-yl-1H-indol-6-yl)urea | - |
Homo sapiens | |
1-methyl-6-[(5-phenyl-1,3-oxazol-2-yl)amino]-1H-indole-3-carbonitrile | - |
Homo sapiens | |
1H-naphtho[2,3-d]imidazol-2-ylmethyl 4-aminobenzoate | binds in the nicotinamide subsite and does not interact with ADP | Cryptosporidium parvum | |
2-(1-benzothiophen-3-yl)-6-methoxy-5-(1,3-oxazol-5-yl)-1H-indole-3-carbaldehyde | - |
Homo sapiens | |
2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide | antagonizes ADP binding | Cryptosporidium parvum | |
2-[2-(Z)-fluorovinyl]-inosine 5'-phosphate | is a time-dependent inactivator | Escherichia coli | |
2-[methyl[2-(2-[[3-(1,3-oxazol-5-yl)-1H-indol-6-yl]amino]-1,3-oxazol-5-yl)phenyl]amino]-2-oxoethyl acetate | - |
Homo sapiens | |
2264A | inhibits lymphocyte proliferation; inhibits lymphocyte proliferation | Homo sapiens | |
2264B | inhibits lymphocyte proliferation; inhibits lymphocyte proliferation | Homo sapiens | |
3-hydrogenkwadaphnin | - |
Homo sapiens | |
4-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-6-phenyl-1,3,5-triazin-2-ol | - |
Homo sapiens | |
5-bromoisoquinolin-6-amine | - |
Homo sapiens | |
5-chloro-1,4-dimethyl-2H-cyclopenta[d]pyridazine-6-carbonitrile | - |
Homo sapiens | |
6,6'-oxydi(1,4-dihydroquinoxaline-2,3-dione) | binds in the nicotinamide subsite and does not interact with ADP | Cryptosporidium parvum | |
6-chloroinosine 5'-phosphate | - |
Homo sapiens | |
6-Cl-IMP | - |
Klebsiella aerogenes | |
7-methoxy-2-(3-methylphenyl)-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one | - |
Homo sapiens | |
7-methoxy-6-(1,3-oxazol-5-yl)-3-(2-pyridin-4-ylethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one | - |
Homo sapiens | |
ADP | - |
Cryptosporidium parvum | |
ADP | - |
Homo sapiens | |
ADP | binds in the adenosine portion, tiazofurin and ADP are strongly synergistic inhibitors, a conformational change occurs upon the binding of one inhibitor that increases the affinity of the second inhibitor | Tritrichomonas suis | |
AVN944 | induces caspase-independent apoptosis in multiple myeloma cell lines and displays antiproliferative activity against both androgen-dependent and androgen-independent prostate cancer cell lines; induces caspase-independent apoptosis in multiple myeloma cell lines and displays antiproliferative activity against both androgen-dependent and androgen-independent prostate cancer cell lines | Homo sapiens | |
benzamide riboside | displays skeletal muscle toxicity in preclinical trials, which limits its utility; displays skeletal muscle toxicity in preclinical trials, which limits its utility | Homo sapiens | |
beta-difluoromethylene-tiazofurin | - |
Homo sapiens | |
beta-methylene-tiazofurin | - |
Homo sapiens | |
blastadin 11 | - |
Homo sapiens | |
EAD | - |
Escherichia coli | |
EICARMP | - |
Escherichia coli | |
EICARMP | - |
Homo sapiens | |
eicosadienoic acid | competitive inhibitor versus IMPDH; competitive inhibitor versus IMPDH | Homo sapiens | |
ethyl 9-oxo-9,10-dihydroacridine-1-carboxylate | - |
Homo sapiens | |
FFAD | - |
Homo sapiens | |
halicyclamine A | - |
Homo sapiens | |
helenalin | - |
Homo sapiens | |
imidazo[4,5-e][1,4]diazapine | fat base nucleotide, inosine 5'-phosphate but not NAD+ protects against inhibition | Escherichia coli | |
imidazo[4,5-e][1,4]diazapine | fat base nucleotide, inosine 5'-phosphate but not NAD+ protects against inhibition; fat base nucleotide, inosine 5'-phosphate but not NAD+ protects against inhibition | Homo sapiens | |
Li+ | - |
Borreliella burgdorferi | |
Li+ | - |
Escherichia coli | |
linoleic acid | - |
Homo sapiens | |
merimepodib | has immunosuppressive activity; has immunosuppressive activity | Homo sapiens | |
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate | antagonizes ADP binding | Cryptosporidium parvum | |
mizoribine | - |
Candida albicans | |
mizoribine | - |
Eimeria tenella | |
mizoribine | - |
Escherichia coli | |
mizoribine | - |
Homo sapiens | |
mizoribine | - |
Leishmania donovani | |
mizoribine | - |
Plasmodium falciparum | |
mizoribine | - |
Staphylococcus aureus | |
mizoribine | - |
Tritrichomonas suis | |
mizoribine | - |
Trypanosoma brucei | |
additional information | IMPDH2 interacts with protein kinase B/Akt via its plekstrin homology domain, the resulting phosphorylation reduces activity | Homo sapiens | |
additional information | becomes resistant to IMPDH inhibitors by rearranging its purine salvage pathways to rely on xanthine instead of hypoxanthine | Tritrichomonas suis | |
Mycophenolic acid | - |
Candida albicans | |
Mycophenolic acid | - |
Eimeria tenella | |
Mycophenolic acid | - |
Homo sapiens | |
Mycophenolic acid | - |
Leishmania donovani | |
Mycophenolic acid | - |
Plasmodium falciparum | |
Mycophenolic acid | - |
Staphylococcus aureus | |
Mycophenolic acid | - |
Tritrichomonas suis | |
Mycophenolic acid | - |
Trypanosoma brucei | |
N-(4-chlorophenyl)-2-phenoxypropanamide | antagonizes ADP binding | Cryptosporidium parvum | |
N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide | binds in the nicotinamide subsite and does not interact with ADP | Cryptosporidium parvum | |
N-(4-methoxyphenyl)-2-naphthalen-1-ylacetamide | binds in the nicotinamide subsite and does not interact with ADP | Cryptosporidium parvum | |
N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide | binds in the nicotinamide subsite and does not interact with ADP | Cryptosporidium parvum | |
N-(5-phenyl-1,3-oxazol-2-yl)isoquinolin-6-amine | - |
Homo sapiens | |
N-[(Z)-(pyridin-3-ylimino)methyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide | - |
Cryptosporidium parvum | |
N-[1-[6-(4-ethylpiperazin-1-yl)pyridin-3-yl]-1-methylethyl]-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide | - |
Homo sapiens | |
N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-2-morpholin-4-ylacetamide | - |
Homo sapiens | |
N-[2-(hydroxymethyl)cyclopentyl]-N'-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]propanediamide | - |
Homo sapiens | |
Na+ | - |
Borreliella burgdorferi | |
Na+ | - |
Escherichia coli | |
pellynic acid | - |
Homo sapiens | |
phenyl N'-cyano-N-(3-[cyano[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamimidamido]benzyl)imidocarbamate | - |
Homo sapiens | |
ribavirin | - |
Homo sapiens | |
ribavirin | - |
Tritrichomonas suis | |
Selenazofurin | - |
Homo sapiens | |
SFAD | - |
Homo sapiens | |
tert-butyl methyl (1S,4S)-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-quinazoline]-3,4-dicarboxylate | - |
Homo sapiens | |
TFAD | - |
Homo sapiens | |
tiazofurin | - |
Cryptosporidium parvum | |
tiazofurin | - |
Homo sapiens | |
tiazofurin | binds in the nicotinamide portion of the dinucleotide site, tiazofurin and ADP are strongly synergistic inhibitors, a conformational change occurs upon the binding of one inhibitor that increases the affinity of the second inhibitor | Tritrichomonas suis | |
VX-148 | has immunosuppressive activity; has immunosuppressive activity | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cs+ | activates | Escherichia coli | |
Cs+ | activates | Borreliella burgdorferi | |
K+ | - |
Streptococcus pyogenes | |
K+ | activates | Escherichia coli | |
K+ | activates | Homo sapiens | |
K+ | activates | Tritrichomonas suis | |
K+ | activates | Borreliella burgdorferi | |
additional information | Li+ has no effect on activity of IMPDH2 | Homo sapiens | |
additional information | Na+ has no effect on activity | Cryptosporidium parvum | |
Na+ | activates | Homo sapiens | |
Na+ | activates | Tritrichomonas suis | |
NH4+ | activates | Escherichia coli | |
NH4+ | activates | Homo sapiens | |
NH4+ | activates | Borreliella burgdorferi | |
Rb+ | activates | Homo sapiens | |
Tl+ | activates | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Borreliella burgdorferi | P49058 | - |
- |
Candida albicans | - |
- |
- |
Cricetulus griseus | - |
Chinese hamster type 2 | - |
Cryptosporidium parvum | Q8T6T2 | - |
- |
Eimeria tenella | - |
- |
- |
Escherichia coli | - |
- |
- |
Homo sapiens | P12268 | - |
- |
Homo sapiens | P20839 | - |
- |
Klebsiella aerogenes | - |
- |
- |
Leishmania donovani | P21620 | - |
- |
no activity in Giardia lamblia | - |
- |
- |
no activity in Trichomonas vaginalis | - |
- |
- |
Plasmodium falciparum | - |
- |
- |
Pneumocystis carinii | Q12658 | - |
- |
Pyrococcus horikoshii | - |
- |
- |
Staphylococcus aureus | - |
- |
- |
Streptococcus pyogenes | P0C0H6 | - |
- |
Toxoplasma gondii | - |
- |
- |
Tritrichomonas suis | P50097 | - |
- |
Trypanosoma brucei | P50098 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
myeloma cell | - |
Homo sapiens | - |
peripheral blood mononuclear cell | - |
Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
retina | - |
Homo sapiens | - |
retina | IMPDH1 predominates in the adult retina | Homo sapiens | - |
spleen | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | - |
Cricetulus griseus | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Staphylococcus aureus | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Escherichia coli | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Klebsiella aerogenes | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Candida albicans | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Plasmodium falciparum | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Eimeria tenella | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Pyrococcus horikoshii | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Homo sapiens | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Tritrichomonas suis | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Cryptosporidium parvum | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Leishmania donovani | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Trypanosoma brucei | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Streptococcus pyogenes | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Pneumocystis carinii | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Borreliella burgdorferi | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
additional information | the CBS subdomain of IMPDH coordinately regulates the adenine and guanine nucleotide pool | Escherichia coli | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | crystallography | Streptococcus pyogenes |
Synonyms | Comment | Organism |
---|---|---|
IMPDH | - |
Cricetulus griseus |
IMPDH | - |
Staphylococcus aureus |
IMPDH | - |
Escherichia coli |
IMPDH | - |
Klebsiella aerogenes |
IMPDH | - |
Candida albicans |
IMPDH | - |
Plasmodium falciparum |
IMPDH | - |
Eimeria tenella |
IMPDH | - |
Pyrococcus horikoshii |
IMPDH | - |
Toxoplasma gondii |
IMPDH | - |
Tritrichomonas suis |
IMPDH | - |
Cryptosporidium parvum |
IMPDH | - |
Leishmania donovani |
IMPDH | - |
Trypanosoma brucei |
IMPDH | - |
Streptococcus pyogenes |
IMPDH | - |
Pneumocystis carinii |
IMPDH | - |
Borreliella burgdorferi |
IMPDH1 | - |
Homo sapiens |
IMPDH2 | - |
Homo sapiens |
inosine 5'-monophosphate dehydrogenase | - |
Cricetulus griseus |
inosine 5'-monophosphate dehydrogenase | - |
Staphylococcus aureus |
inosine 5'-monophosphate dehydrogenase | - |
Escherichia coli |
inosine 5'-monophosphate dehydrogenase | - |
Klebsiella aerogenes |
inosine 5'-monophosphate dehydrogenase | - |
Candida albicans |
inosine 5'-monophosphate dehydrogenase | - |
Plasmodium falciparum |
inosine 5'-monophosphate dehydrogenase | - |
Eimeria tenella |
inosine 5'-monophosphate dehydrogenase | - |
Pyrococcus horikoshii |
inosine 5'-monophosphate dehydrogenase | - |
Toxoplasma gondii |
inosine 5'-monophosphate dehydrogenase | - |
Homo sapiens |
inosine 5'-monophosphate dehydrogenase | - |
Tritrichomonas suis |
inosine 5'-monophosphate dehydrogenase | - |
Cryptosporidium parvum |
inosine 5'-monophosphate dehydrogenase | - |
Leishmania donovani |
inosine 5'-monophosphate dehydrogenase | - |
Trypanosoma brucei |
inosine 5'-monophosphate dehydrogenase | - |
Streptococcus pyogenes |
inosine 5'-monophosphate dehydrogenase | - |
Pneumocystis carinii |
inosine 5'-monophosphate dehydrogenase | - |
Borreliella burgdorferi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Cricetulus griseus | |
NAD+ | - |
Staphylococcus aureus | |
NAD+ | - |
Escherichia coli | |
NAD+ | - |
Klebsiella aerogenes | |
NAD+ | - |
Candida albicans | |
NAD+ | - |
Plasmodium falciparum | |
NAD+ | - |
Eimeria tenella | |
NAD+ | - |
Pyrococcus horikoshii | |
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Tritrichomonas suis | |
NAD+ | - |
Cryptosporidium parvum | |
NAD+ | - |
Leishmania donovani | |
NAD+ | - |
Trypanosoma brucei | |
NAD+ | - |
Streptococcus pyogenes | |
NAD+ | - |
Pneumocystis carinii | |
NAD+ | - |
Borreliella burgdorferi |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000005 | - |
mizoribine | - |
Escherichia coli | |
0.000001 | - |
imidazo[4,5-e][1,4]diazapine | - |
Homo sapiens | |
0.000006 | - |
VX-148 | - |
Homo sapiens | |
0.000006 | - |
AVN944 | - |
Homo sapiens | |
0.000007 | - |
merimepodib | - |
Homo sapiens | |
0.000008 | - |
mizoribine | - |
Homo sapiens | |
0.000014 | - |
VX-148 | - |
Homo sapiens | |
0.00002 | - |
Selenazofurin | with inosine 5'-phosphate as substrate | Homo sapiens | |
0.00003 | - |
Selenazofurin | with inosine 5'-phosphate as substrate | Homo sapiens | |
0.00005 | - |
imidazo[4,5-e][1,4]diazapine | IMPDH2 | Escherichia coli | |
0.00043 | - |
tiazofurin | with inosine 5'-phosphate as substrate | Homo sapiens | |
0.00043 | - |
TFAD | with inosine 5'-phosphate as substrate | Homo sapiens | |
0.00058 | - |
SFAD | with inosine 5'-phosphate as substrate | Homo sapiens | |
0.0007 | - |
tiazofurin | with inosine 5'-phosphate as substrate | Homo sapiens | |
0.0007 | - |
TFAD | with inosine 5'-phosphate as substrate | Homo sapiens | |
0.001 | - |
2-[2-(Z)-fluorovinyl]-inosine 5'-phosphate | - |
Escherichia coli | |
0.0011 | - |
SFAD | with inosine 5'-phosphate as substrate | Homo sapiens | |
0.002 | - |
EICARMP | - |
Escherichia coli | |
0.003 | - |
eicosadienoic acid | - |
Homo sapiens | |
0.016 | - |
EICARMP | - |
Homo sapiens | |
0.027 | - |
EAD | - |
Escherichia coli | |
0.038 | - |
FFAD | with inosine 5'-phosphate as substrate | Homo sapiens | |
0.056 | - |
FFAD | with inosine 5'-phosphate as substrate | Homo sapiens | |
0.078 | - |
6-chloroinosine 5'-phosphate | - |
Homo sapiens | |
0.26 | - |
6-Cl-IMP | - |
Klebsiella aerogenes | |
1.3 | - |
tiazofurin | - |
Homo sapiens | |
1.5 | - |
tiazofurin | - |
Cryptosporidium parvum | |
8.8 | - |
ADP | - |
Homo sapiens | |
31 | - |
ADP | - |
Tritrichomonas suis | |
42 | - |
ADP | - |
Cryptosporidium parvum | |
50 | - |
tiazofurin | - |
Tritrichomonas suis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000005 | - |
- |
Homo sapiens | 7-methoxy-2-(3-methylphenyl)-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one | |
0.000005 | - |
- |
Homo sapiens | N-(5-phenyl-1,3-oxazol-2-yl)isoquinolin-6-amine | |
0.000007 | - |
- |
Homo sapiens | 2-[methyl[2-(2-[[3-(1,3-oxazol-5-yl)-1H-indol-6-yl]amino]-1,3-oxazol-5-yl)phenyl]amino]-2-oxoethyl acetate | |
0.000012 | - |
- |
Homo sapiens | N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-2-morpholin-4-ylacetamide | |
0.000013 | - |
- |
Homo sapiens | 7-methoxy-6-(1,3-oxazol-5-yl)-3-(2-pyridin-4-ylethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one | |
0.000016 | - |
- |
Homo sapiens | phenyl N'-cyano-N-(3-[cyano[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamimidamido]benzyl)imidocarbamate | |
0.000017 | - |
- |
Homo sapiens | N-[1-[6-(4-ethylpiperazin-1-yl)pyridin-3-yl]-1-methylethyl]-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide | |
0.000018 | - |
- |
Homo sapiens | 4-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-6-phenyl-1,3,5-triazin-2-ol | |
0.000018 | - |
- |
Homo sapiens | N-[2-(hydroxymethyl)cyclopentyl]-N'-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]propanediamide | |
0.000028 | - |
- |
Homo sapiens | (2E)-3-furan-2-yl-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]prop-2-enamide | |
0.00003 | - |
- |
Homo sapiens | 2-(1-benzothiophen-3-yl)-6-methoxy-5-(1,3-oxazol-5-yl)-1H-indole-3-carbaldehyde | |
0.000033 | - |
- |
Homo sapiens | 1-methyl-6-[(5-phenyl-1,3-oxazol-2-yl)amino]-1H-indole-3-carbonitrile | |
0.000035 | - |
- |
Homo sapiens | tert-butyl methyl (1S,4S)-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-quinazoline]-3,4-dicarboxylate | |
0.000076 | - |
- |
Homo sapiens | 1-(benzyloxy)-3-(3-pyridin-4-yl-1H-indol-6-yl)urea | |
0.0005 | - |
- |
Homo sapiens | 5-bromoisoquinolin-6-amine | |
0.00073 | - |
- |
Homo sapiens | ethyl 9-oxo-9,10-dihydroacridine-1-carboxylate | |
0.00076 | - |
- |
Homo sapiens | 5-chloro-1,4-dimethyl-2H-cyclopenta[d]pyridazine-6-carbonitrile | |
0.001 | - |
- |
Homo sapiens | pellynic acid | |
0.0019 | - |
- |
Homo sapiens | 1,4-dimethyl-6-nitro-2H-cyclopenta[d]pyridazine | |
0.07 | - |
- |
Homo sapiens | 2264A |
General Information | Comment | Organism |
---|---|---|
physiological function | mutations in the CBS subdomain of IMPDH1 account for 2-3% of autosomal dominant retinitis pigmentosa | Homo sapiens |