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Literature summary for 1.1.1.205 extracted from

  • Vethe, N.T.; Bremer, S.; Bergan, S.
    IMP dehydrogenase basal activity in MOLT-4 human leukaemia cells is altered by mycophenolic acid and 6-thioguanosine (2007), Scand. J. Clin. Lab. Invest., 68, 277-285.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
6-thioguanosine expression of isoform IMPDH2 increases modestly in response to 6-thioguanosine exposure. However, the basal enzyme activity decreases when the cells are exposed to a proliferation-blocking 6-thioguanosine concentration Homo sapiens
Mycophenolic acid biphasic concentration-dependent influence on inosine 5'-phosphate dehydrogenase basal activity. At concentrations around or below IC50 value, mycophenolic acid increases the basal enzymic activity, associated with elevated expression of isoform IMPDH2. Despite increased expression, the basal enzyme activity decreases following exposure to high mycophenolic acid concentrations Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
MOLT-4 cell leukemia cell Homo sapiens
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