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Literature summary for 1.1.1.205 extracted from

  • Iwanowicz, E.J.; Watterson, S.H.; Guo, J.; Pitts, W.J.; Dhar, T.G.M.; Shen, Z.; Chen, P.; Gu, H.H.; Fleener, C.A.; Rouleau, K.A.; Cheney, D.L.; Townsend, R.M.; Hollenbaugh, D.M.
    Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-methoxy-4-(5-oxazolyl)phenyl] moiety (2003), Bioorg. Med. Chem. Lett., 13, 2059-2063.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2E)-3-furan-2-yl-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]prop-2-enamide isozyme IMPDH II IC50: 28 nM Homo sapiens
(2E)-3-furan-2-yl-N-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]prop-2-enamide isozyme IMPDH II IC50: 0.002 mM Homo sapiens
1-(3-methylphenyl)-3-[4-(1,3-oxazol-5-yl)phenyl]urea isozyme IMPDH II IC50: 640 nM Homo sapiens
1-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea isozyme IMPDH II IC50: 43 nM Homo sapiens
1-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea isozyme IMPDH II IC50: 19 nM Homo sapiens
1-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea isozyme IMPDH II IC50: 500 nM Homo sapiens
2-(1,3-oxazol-5-yl)-5-[(5-phenyl-1,3-oxazol-2-yl)amino]phenol isozyme IMPDH II IC50: 0.0016 mM Homo sapiens
2-cyano-1-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-3-phenylguanidine isozyme IMPDH II IC50: 240 nM Homo sapiens
2-hydroxy-N-[2-(2-[[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methylacetamide isozyme IMPDH II IC50: 41 nM Homo sapiens
3-hydroxy-N-methyl-N-[2-(2-[[3-methyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]propanamide isozyme IMPDH II IC50: 100 nM Homo sapiens
3-hydroxy-N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methylpropanamide isozyme IMPDH II IC50: 21 nM Homo sapiens
7-methoxy-6-(1,3-oxazol-4-yl)-2-phenylquinolin-4(1H)-one isozyme IMPDH II IC50: 210 nM Homo sapiens
7-methoxy-6-(1,3-oxazol-5-yl)-2-phenoxyquinolin-4(1H)-one isozyme IMPDH II IC50: 8 nM Homo sapiens
additional information determination and analysis of structure-activity relationships of the different inhibitor molecules, overview Homo sapiens
Mycophenolic acid key binding interactions for the benzofuranone residue mycophenolic acid and the N-[3-methoxy-4-(5-oxazolyl)phenyl] fragment of VX-497, the benzofuranone ring mycophenolic acid binds in a spatially restricted region of the NAD+ binding site packing with the hypoxanthine ring xanthosine 5'-phosphate, the carbonyl oxygen and hydroxy residues are involved in a hydrogen bond array that involves Gly326, Thr333 and Gln441, the appending methyl substituent of the benzofuranone system, resides in a small hydrophobic pocket defined by the planes of Asn303 amide and Arg322 guanidine, the phenyl oxazole moiety of VX-497 binds in the same region as the benzofuranone ring of mycophenolic acid, forming hydrogen bonds between the oxazole nitrogen and oxygen with Gly326 and possibly Thr333, respectively, the methoxy residue binds in the same pocket as the benzofuranone methyl in mycophenolic acid Homo sapiens
N-methyl-N'-[4-(1,3-oxazol-5-yl)phenyl]-6-phenyl-1,3,5-triazine-2,4-diamine isozyme IMPDH II IC50: 0.005 mM Homo sapiens
N-methyl-N'-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-6-phenyl-1,3,5-triazine-2,4-diamine isozyme IMPDH II IC50: 0.005 mM Homo sapiens
N-methyl-N-[2-(2-[[3-methyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-morpholin-4-ylpropanamide isozyme IMPDH II IC50: 45 nM Homo sapiens
N-tert-butyl-N'-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]ethanediamide isozyme IMPDH II IC50: 55 nM Homo sapiens
N-tert-butyl-N'-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]ethanediamide isozyme IMPDH II IC50: 10 nM Homo sapiens
N-tert-butyl-N'-[4-(1,3-oxazol-5-yl)phenyl]ethanediamide isozyme IMPDH II IC50: 0.005 mM Homo sapiens
N-tert-butyl-N'-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]ethanediamide isozyme IMPDH II IC50: 0.005 mM Homo sapiens
N-[2-(2-[[3-(chloromethyl)-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide isozyme IMPDH II IC50: 47 nM Homo sapiens
N-[2-(2-[[3-bromo-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide isozyme IMPDH II IC50: 28 nM Homo sapiens
N-[2-(2-[[3-bromo-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide isozyme IMPDH II IC50: 21 nM Homo sapiens
N-[2-(2-[[3-chloro-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide isozyme IMPDH II IC50: 48 nM Homo sapiens
N-[2-(2-[[3-ethyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide isozyme IMPDH II IC50: 310 nM Homo sapiens
N-[2-(2-[[3-ethyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide isozyme IMPDH II IC50: 21 nM Homo sapiens
N-[2-(2-[[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-2-morpholin-4-ylacetamide isozyme IMPDH II IC50: 91 nM Homo sapiens
N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide isozyme IMPDH II IC50: 16 nM Homo sapiens
N-[2-chloro-3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 0.005 mM Homo sapiens
N-[2-chloro-5-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 0.0016 mM Homo sapiens
N-[2-fluoro-5-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 0.005 mM Homo sapiens
N-[3-bromo-4-(1,3-oxazol-5-yl)phenyl]-N'-tert-butylethanediamide isozyme IMPDH II IC50: 50 nM Homo sapiens
N-[3-chloro-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 0.005 mM Homo sapiens
N-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 88 nM Homo sapiens
N-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine isozyme IMPDH II IC50: 340 nM Homo sapiens
N-[3-ethoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 0.010 mM Homo sapiens
N-[3-methoxy-4-(1,3-oxazol-2-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 190 nM Homo sapiens
N-[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 57 nM Homo sapiens
N-[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine isozyme IMPDH II IC50: 0.0016 mM Homo sapiens
N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 20 nM Homo sapiens
N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine isozyme IMPDH II IC50: 76 nM Homo sapiens
N-[3-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 410 nM Homo sapiens
N-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 0.002 mM Homo sapiens
N-[3-methoxy-4-(4-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 0.005 mM Homo sapiens
N-[3-methyl-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 0.005 mM Homo sapiens
N-[4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 0.005 mM Homo sapiens
N-[4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 0.005 mM Homo sapiens
N-[4-(2,4-dimethyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 0.002 mM Homo sapiens
N-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine isozyme IMPDH II IC50: 0.005 mM Homo sapiens
VX-497 key binding interactions for the benzofuranone residue mycophenolic acid and the N-[3-methoxy-4-(5-oxazolyl)phenyl] fragment of VX-497, the benzofuranone ring mycophenolic acid binds in a spatially restricted region of the NAD+ binding site packing with the hypoxanthine ring xanthosine 5'-phosphate, the carbonyl oxygen and hydroxy residues are involved in a hydrogen bond array that involves Gly326, Thr333 and Gln441, the appending methyl substituent of the benzofuranone system, resides in a small hydrophobic pocket defined by the planes of Asn303 amide and Arg322 guanidine, the phenyl oxazole moiety of VX-497 binds in the same region as the benzofuranone ring of mycophenolic acid, forming hydrogen bonds between the oxazole nitrogen and oxygen with Gly326 and possibly Thr333, respectively, the methoxy residue binds in the same pocket as the benzofuranone methyl in mycophenolic acid Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O Homo sapiens rate-limiting step of the de novo guanine nucleotide biosynthesis xanthosine 5'-phosphate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozyme IMPDH II
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O
-
Homo sapiens xanthosine 5'-phosphate + NADH
-
?
inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis Homo sapiens xanthosine 5'-phosphate + NADH
-
?

Synonyms

Synonyms Comment Organism
IMPDH
-
Homo sapiens
inosine monophosphate dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000008
-
isozyme IMPDH II IC50: 8 nM Homo sapiens 7-methoxy-6-(1,3-oxazol-5-yl)-2-phenoxyquinolin-4(1H)-one
0.00001
-
isozyme IMPDH II IC50: 10 nM Homo sapiens N-tert-butyl-N'-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]ethanediamide
0.000016
-
isozyme IMPDH II IC50: 16 nM Homo sapiens N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide
0.000019
-
isozyme IMPDH II IC50: 19 nM Homo sapiens 1-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea
0.00002
-
isozyme IMPDH II IC50: 20 nM Homo sapiens N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.000021
-
isozyme IMPDH II IC50: 21 nM Homo sapiens 3-hydroxy-N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methylpropanamide
0.000021
-
isozyme IMPDH II IC50: 21 nM Homo sapiens N-[2-(2-[[3-bromo-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide
0.000021
-
isozyme IMPDH II IC50: 21 nM Homo sapiens N-[2-(2-[[3-ethyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide
0.000028
-
isozyme IMPDH II IC50: 28 nM Homo sapiens (2E)-3-furan-2-yl-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]prop-2-enamide
0.000028
-
isozyme IMPDH II IC50: 28 nM Homo sapiens N-[2-(2-[[3-bromo-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide
0.000041
-
isozyme IMPDH II IC50: 41 nM Homo sapiens 2-hydroxy-N-[2-(2-[[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methylacetamide
0.000043
-
isozyme IMPDH II IC50: 43 nM Homo sapiens 1-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea
0.000045
-
isozyme IMPDH II IC50: 45 nM Homo sapiens N-methyl-N-[2-(2-[[3-methyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-morpholin-4-ylpropanamide
0.000047
-
isozyme IMPDH II IC50: 47 nM Homo sapiens N-[2-(2-[[3-(chloromethyl)-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide
0.000048
-
isozyme IMPDH II IC50: 48 nM Homo sapiens N-[2-(2-[[3-chloro-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide
0.00005
-
isozyme IMPDH II IC50: 50 nM Homo sapiens N-[3-bromo-4-(1,3-oxazol-5-yl)phenyl]-N'-tert-butylethanediamide
0.000055
-
isozyme IMPDH II IC50: 55 nM Homo sapiens N-tert-butyl-N'-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]ethanediamide
0.000057
-
isozyme IMPDH II IC50: 57 nM Homo sapiens N-[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.000076
-
isozyme IMPDH II IC50: 76 nM Homo sapiens N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine
0.000088
-
isozyme IMPDH II IC50: 88 nM Homo sapiens N-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.000091
-
isozyme IMPDH II IC50: 91 nM Homo sapiens N-[2-(2-[[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-2-morpholin-4-ylacetamide
0.0001
-
isozyme IMPDH II IC50: 100 nM Homo sapiens 3-hydroxy-N-methyl-N-[2-(2-[[3-methyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]propanamide
0.00019
-
isozyme IMPDH II IC50: 190 nM Homo sapiens N-[3-methoxy-4-(1,3-oxazol-2-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.00021
-
isozyme IMPDH II IC50: 210 nM Homo sapiens 7-methoxy-6-(1,3-oxazol-4-yl)-2-phenylquinolin-4(1H)-one
0.00024
-
isozyme IMPDH II IC50: 240 nM Homo sapiens 2-cyano-1-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-3-phenylguanidine
0.00031
-
isozyme IMPDH II IC50: 310 nM Homo sapiens N-[2-(2-[[3-ethyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide
0.00034
-
isozyme IMPDH II IC50: 340 nM Homo sapiens N-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine
0.00041
-
isozyme IMPDH II IC50: 410 nM Homo sapiens N-[3-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.0005
-
isozyme IMPDH II IC50: 500 nM Homo sapiens 1-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea
0.00064
-
isozyme IMPDH II IC50: 640 nM Homo sapiens 1-(3-methylphenyl)-3-[4-(1,3-oxazol-5-yl)phenyl]urea
0.0016
-
isozyme IMPDH II IC50: 0.0016 mM Homo sapiens 2-(1,3-oxazol-5-yl)-5-[(5-phenyl-1,3-oxazol-2-yl)amino]phenol
0.0016
-
isozyme IMPDH II IC50: 0.0016 mM Homo sapiens N-[2-chloro-5-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.0016
-
isozyme IMPDH II IC50: 0.0016 mM Homo sapiens N-[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine
0.002
-
isozyme IMPDH II IC50: 0.002 mM Homo sapiens (2E)-3-furan-2-yl-N-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]prop-2-enamide
0.002
-
isozyme IMPDH II IC50: 0.002 mM Homo sapiens N-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.002
-
isozyme IMPDH II IC50: 0.002 mM Homo sapiens N-[4-(2,4-dimethyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.005
-
isozyme IMPDH II IC50: 0.005 mM Homo sapiens N-[4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.005
-
isozyme IMPDH II IC50: 0.005 mM Homo sapiens N-[2-fluoro-5-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.005
-
isozyme IMPDH II IC50: 0.005 mM Homo sapiens N-[2-chloro-3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.005
-
isozyme IMPDH II IC50: 0.005 mM Homo sapiens N-tert-butyl-N'-[4-(1,3-oxazol-5-yl)phenyl]ethanediamide
0.005
-
isozyme IMPDH II IC50: 0.005 mM Homo sapiens N-methyl-N'-[4-(1,3-oxazol-5-yl)phenyl]-6-phenyl-1,3,5-triazine-2,4-diamine
0.005
-
isozyme IMPDH II IC50: 0.005 mM Homo sapiens N-methyl-N'-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-6-phenyl-1,3,5-triazine-2,4-diamine
0.005
-
isozyme IMPDH II IC50: 0.005 mM Homo sapiens N-tert-butyl-N'-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]ethanediamide
0.005
-
isozyme IMPDH II IC50: 0.005 mM Homo sapiens N-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.005
-
isozyme IMPDH II IC50: 0.005 mM Homo sapiens N-[3-methoxy-4-(4-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.005
-
isozyme IMPDH II IC50: 0.005 mM Homo sapiens N-[4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.005
-
isozyme IMPDH II IC50: 0.005 mM Homo sapiens N-[3-methyl-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.005
-
isozyme IMPDH II IC50: 0.005 mM Homo sapiens N-[3-chloro-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
0.01
-
isozyme IMPDH II IC50: 0.010 mM Homo sapiens N-[3-ethoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine