Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.205 extracted from

  • Zhou, X.; Cahoon, M.; Rosa, P.; Hedstrom, L.
    Expression, purification, and characterization of inosine 5'-monophosphate dehydrogenase from Borrelia burgdorferi (1997), J. Biol. Chem., 35, 21977-21981.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Borreliella burgdorferi

Inhibitors

Inhibitors Comment Organism Structure
GMP competitive with respect to IMP Borreliella burgdorferi
Mycophenolic acid uncompetitive with respect to IMP and NAD+ Borreliella burgdorferi
NAD+ substrate inhibition at high concentration Borreliella burgdorferi
thiazole-4-carboxamide adenine dinucleotide uncompetitive with respect to IMP and NAD Borreliella burgdorferi
xanthosine 5'-phosphate competitive with respect to IMP Borreliella burgdorferi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Borreliella burgdorferi

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
equilibrium sedimentation results suggest monomeric, dimeric and tetrameric forms and higher order aggregates Borreliella burgdorferi
43640
-
calculated from amino acid composition Borreliella burgdorferi
44000
-
SDS-PAGE Borreliella burgdorferi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O Borreliella burgdorferi subdomain of the enzyme is not required for catalytic activity xanthosine 5'-phosphate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Borreliella burgdorferi
-
-
-

Purification (Commentary)

Purification (Comment) Organism
95% homogeneity Borreliella burgdorferi

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.83
-
-
Borreliella burgdorferi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O subdomain of the enzyme is not required for catalytic activity Borreliella burgdorferi xanthosine 5'-phosphate + NADH
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0433
-
NAD+
-
Borreliella burgdorferi

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Borreliella burgdorferi