Literature summary for 1.1.1.205 extracted from

Farazi, t.; Leichman, J.; Harris, T.; Cahoon, M.; Hedstrom, L.
Isolation and characterization onf mycophenolic acid-resistant mutants of inosine-5'-monophosphate dehydrogenase (1997), J. Biol. Chem., 272, 961-965.

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Protein Variants

Protein Variants	Comment	Organism
A462T	increase in the Ki for mycophenolic acid	Homo sapiens
F465S/N470G	increase in the Ki for mycophenolic acid	Homo sapiens
Q277R	increase in the Ki for mycophenolic acid	Homo sapiens
Q277R/A462T	increase in the Ki for mycophenolic acid	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Mycophenolic acid	mutants have increased Ki for MPA	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	wild type and mutants of type II	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	mutants of type II	-
Homo sapiens	-	type II	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	wild type and mutants	Homo sapiens

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Release 2023.1 (January 2023)