Literature summary for 1.1.1.205 extracted from

Anderson, J.H.; Sartorelli, A.C.
Inosinic acid dehydrogenase of sarcoma 180 cells (1968), J. Biol. Chem., 243, 4762-4768.

Search for more literature for 1.1.1.205

Inhibitors

Inhibitors	Comment	Organism	Structure
AMP	20% inhibition at high concentrations	Mus musculus
Ca2+	29% inactivation in the presence of 0.1M K+	Mus musculus
Li+	inhibits stimulatory effect of K+	Mus musculus
Mg2+	inhibits K+ activation	Mus musculus
additional information	-	Mus musculus
NAD+	substrate inhibition at high concentration	Mus musculus
NADH	non competitive with respect to NAD+	Mus musculus
xanthosine 5'-phosphate	competitive with respect to IMP	Mus musculus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	-	Mus musculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
K+	activation	Mus musculus
K+	0.1 M	Mus musculus
Na+	can partially replace K+ in activation	Mus musculus
NH4+	K+ can be partially replaced by NH4+	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partial purification	Mus musculus

Reaction

Reaction	Comment	Organism	Reaction ID
IMP + NAD+ + H2O = XMP + NADH + H+	ordered sequential mechanism	Mus musculus	a
IMP + NAD+ + H2O = XMP + NADH + H+	sequential addition of IMP, NAD+ and K+	Mus musculus	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
inosine 5'-phosphate + NAD+ + H2O	-	Mus musculus	xanthosine 5'-phosphate + NADH	-	ir

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Mus musculus

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Release 2023.1 (January 2023)