Literature summary for 1.1.1.205 extracted from

Nichol, A.W.; Nomura, A.; Hampton, A.
Studies on phosphate binding sites of inosinic acid dehydrogenase and adenylosuccinate synthetase (1967), Biochemistry, 6, 1008-1015.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Inosine	very weak, non-competitive	Klebsiella aerogenes
Inosine 5'-methylphosphonate	very weak, non-competitive	Klebsiella aerogenes
Inosine 5'-phosphite	very weak, non-competitive	Klebsiella aerogenes
Inosine 5'-phosphofluoridate	very weak, non-competitive	Klebsiella aerogenes
phosphate	mixed inhibition kinetics	Klebsiella aerogenes
ribose 5-phosphate	non-competitive	Klebsiella aerogenes

Organism

Organism	UniProt	Comment	Textmining
Klebsiella aerogenes	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
inosine 5'-phosphate + NAD+ + H2O	-	Klebsiella aerogenes	xanthosine 5'-phosphate + NADH	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Klebsiella aerogenes

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	-	Klebsiella aerogenes

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Release 2023.1 (January 2023)