Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Bredinin | - |
Chlorocebus aethiops | |
ribavirin | potent competitive inhibition, shows anti-viral activity in vivo, detailed overview | Parainfluenza virus | |
ribavirin | potent competitive inhibition, shows anti-viral activity in vivo, detailed overview | Vaccinia virus | |
ribavirin 5'-monophosphate | - |
Chlorocebus aethiops | |
Selenazofurin | inhibition (in vivo) by the NAD analog formed intracellularly | Chlorocebus aethiops | |
Selenazofurin | potent competitive inhibition, shows anti-viral activity in vivo, detailed overview, a complete reversal of the antiviral activity of selenazofurin was obtained by addition of guanosine and selenazofurin at varying concentrations | Parainfluenza virus | |
Selenazofurin | potent competitive inhibition, shows anti-viral activity in vivo, detailed overview | Vaccinia virus | |
thiazole-4-carboxamide adenine dinucleotide | - |
Chlorocebus aethiops | |
tiazofurin | - |
Chlorocebus aethiops | |
tiazofurin | - |
Parainfluenza virus | |
tiazofurin | - |
Vaccinia virus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | Vaccinia virus | rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview | xanthosine 5'-phosphate + NADH | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | Parainfluenza virus | rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview | xanthosine 5'-phosphate + NADH | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | Vaccinia virus Elstree | rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview | xanthosine 5'-phosphate + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chlorocebus aethiops | - |
vero cell-line infected with vaccina virus and parainfluenza virus type 3 strain C243 | - |
Parainfluenza virus | - |
type 3, strain C243, propagated in Vero cells | - |
Vaccinia virus | - |
propagated in Vero cells | - |
Vaccinia virus Elstree | - |
propagated in Vero cells | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | - |
Vaccinia virus | xanthosine 5'-phosphate + NADH | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Chlorocebus aethiops | xanthosine 5'-phosphate + NADH | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Parainfluenza virus | xanthosine 5'-phosphate + NADH | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview | Vaccinia virus | xanthosine 5'-phosphate + NADH | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview | Parainfluenza virus | xanthosine 5'-phosphate + NADH | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | - |
Vaccinia virus Elstree | xanthosine 5'-phosphate + NADH | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview | Vaccinia virus Elstree | xanthosine 5'-phosphate + NADH | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Chlorocebus aethiops | |
NAD+ | - |
Parainfluenza virus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00025 | - |
ribavirin 5'-monophosphate | - |
Chlorocebus aethiops |