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Literature summary for 1.1.1.205 extracted from

  • Hupe, D.J.; Azzolina, B.A.; Behrens, N.D.
    IMP dehydrogenase from the intracellular parasitic protozoan Eimeria tenella and its inhibition by mycophenolic acid (1986), J. Biol. Chem., 261, 8363-8369.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Mycophenolic acid 50% inhibition at 0.0003 mM, reversible by guanine Eimeria tenella
NADH
-
Eimeria tenella

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
IMP
-
Eimeria tenella
0.15
-
NAD+
-
Eimeria tenella

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Eimeria tenella
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Eimeria tenella

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
-
Eimeria tenella
-

Storage Stability

Storage Stability Organism
-80°C, most activity is lost Eimeria tenella

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O
-
Eimeria tenella xanthosine 5'-phosphate + NADH
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
increase of activity with increasing pH up to 8.5 Eimeria tenella

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Eimeria tenella

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000071
-
Mycophenolic acid at a fixed concentration of 0.5 mM NAD+ and 0.03 mM IMP Eimeria tenella
0.000178
-
Mycophenolic acid at a fixed concentration of 0.5 mM NAD+ Eimeria tenella
0.00069
-
Mycophenolic acid
-
Eimeria tenella
0.00069
-
Mycophenolic acid at a fixed concentration of 0.03 mM IMP Eimeria tenella