Application | Comment | Organism |
---|---|---|
synthesis | the enzyme is useful in production of ursodeoxycholic acid, a secondary bile acid, which is used as a drug for the treatment of various liver diseases | Clostridium sardiniense |
synthesis | the enzyme is useful in production of ursodeoxycholic acid, a secondary bile acid, which is used as a drug for the treatment of various liver diseases | Paeniclostridium sordellii |
synthesis | the enzyme is useful in production of ursodeoxycholic acid, a secondary bile acid, which is used as a drug for the treatment of various liver diseases | Fusarium equiseti |
synthesis | the enzyme is useful in production of ursodeoxycholic acid, a secondary bile acid, which is used as a drug for the treatment of various liver diseases | [Clostridium] scindens |
synthesis | the enzyme is useful in production of ursodeoxycholic acid, a secondary bile acid, which is used as a drug for the treatment of various liver diseases | Collinsella aerofaciens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | development and evaluation of a selected multi-step reaction system for the synthesis of ursodeoxycholic acid, separation of each step by isolation of the intermediates using ultrafiltration membranes, overview | Clostridium sardiniense |
additional information | development and evaluation of a selected multi-step reaction system for the synthesis of ursodeoxycholic acid, separation of each step by isolation of the intermediates using ultrafiltration membranes, overview | Paeniclostridium sordellii |
additional information | development and evaluation of a selected multi-step reaction system for the synthesis of ursodeoxycholic acid, separation of each step by isolation of the intermediates using ultrafiltration membranes, overview | Fusarium equiseti |
additional information | development and evaluation of a selected multi-step reaction system for the synthesis of ursodeoxycholic acid, separation of each step by isolation of the intermediates using ultrafiltration membranes, overview | [Clostridium] scindens |
additional information | development and evaluation of a selected multi-step reaction system for the synthesis of ursodeoxycholic acid, separation of each step by isolation of the intermediates using ultrafiltration membranes, overview | Collinsella aerofaciens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
chenodeoxycholic acid + NADPH + H+ | Clostridium sardiniense | - |
ursodeoxycholic acid + NADP+ | - |
? | |
chenodeoxycholic acid + NADPH + H+ | Paeniclostridium sordellii | - |
ursodeoxycholic acid + NADP+ | - |
? | |
chenodeoxycholic acid + NADPH + H+ | Fusarium equiseti | - |
ursodeoxycholic acid + NADP+ | - |
? | |
chenodeoxycholic acid + NADPH + H+ | [Clostridium] scindens | - |
ursodeoxycholic acid + NADP+ | - |
? | |
chenodeoxycholic acid + NADPH + H+ | Collinsella aerofaciens | - |
ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | Paeniclostridium sordellii | - |
ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | Fusarium equiseti | - |
ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | [Clostridium] scindens | - |
ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | Collinsella aerofaciens | - |
ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | Clostridium sardiniense | presence of both 7alpha-HSDH (EC 1.1.1.159) and 7beta-HSDH in one organism allows epimerization by a single bacterium | ursodeoxycholic acid + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium sardiniense | - |
- |
- |
Collinsella aerofaciens | - |
- |
- |
Fusarium equiseti | - |
- |
- |
Paeniclostridium sordellii | - |
- |
- |
[Clostridium] scindens | - |
formerly Eubacterium sp. | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
350 | - |
pH and temperature not specified in the publication | Paeniclostridium sordellii |
350 | - |
pH and temperature not specified in the publication | [Clostridium] scindens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,12-dioxo-ursodeoxycholic acid + NADPH + H+ | - |
Clostridium sardiniense | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
7,12-dioxo-ursodeoxycholic acid + NADPH + H+ | - |
Paeniclostridium sordellii | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
7,12-dioxo-ursodeoxycholic acid + NADPH + H+ | - |
Fusarium equiseti | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
7,12-dioxo-ursodeoxycholic acid + NADPH + H+ | - |
[Clostridium] scindens | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
7,12-dioxo-ursodeoxycholic acid + NADPH + H+ | - |
Collinsella aerofaciens | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
chenodeoxycholic acid + NADPH + H+ | - |
Clostridium sardiniense | ursodeoxycholic acid + NADP+ | - |
? | |
chenodeoxycholic acid + NADPH + H+ | - |
Paeniclostridium sordellii | ursodeoxycholic acid + NADP+ | - |
? | |
chenodeoxycholic acid + NADPH + H+ | - |
Fusarium equiseti | ursodeoxycholic acid + NADP+ | - |
? | |
chenodeoxycholic acid + NADPH + H+ | - |
[Clostridium] scindens | ursodeoxycholic acid + NADP+ | - |
? | |
chenodeoxycholic acid + NADPH + H+ | - |
Collinsella aerofaciens | ursodeoxycholic acid + NADP+ | - |
? | |
dehydrocholic acid + NADPH + H+ | - |
Clostridium sardiniense | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
dehydrocholic acid + NADPH + H+ | - |
Paeniclostridium sordellii | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
dehydrocholic acid + NADPH + H+ | - |
Fusarium equiseti | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
dehydrocholic acid + NADPH + H+ | - |
[Clostridium] scindens | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
dehydrocholic acid + NADPH + H+ | - |
Collinsella aerofaciens | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | - |
Clostridium sardiniense | ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | - |
Paeniclostridium sordellii | ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | - |
Fusarium equiseti | ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | - |
[Clostridium] scindens | ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | - |
Collinsella aerofaciens | ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | presence of both 7alpha-HSDH (EC 1.1.1.159) and 7beta-HSDH in one organism allows epimerization by a single bacterium | Clostridium sardiniense | ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | presence of both 7alpha-HSDH (EC 1.1.1.159) and 7beta-HSDH in one organism allows epimerization by a single bacterium | Paeniclostridium sordellii | ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | presence of both 7alpha-HSDH (EC 1.1.1.159) and 7beta-HSDH in one organism allows epimerization by a single bacterium | Fusarium equiseti | ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | presence of both 7alpha-HSDH (EC 1.1.1.159) and 7beta-HSDH in one organism allows epimerization by a single bacterium | [Clostridium] scindens | ursodeoxycholic acid + NADP+ | - |
? | |
lithocholic acid + NADPH + H+ | presence of both 7alpha-HSDH (EC 1.1.1.159) and 7beta-HSDH in one organism allows epimerization by a single bacterium | Collinsella aerofaciens | ursodeoxycholic acid + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
7beta-HSDH | - |
Clostridium sardiniense |
7beta-HSDH | - |
Paeniclostridium sordellii |
7beta-HSDH | - |
Fusarium equiseti |
7beta-HSDH | - |
[Clostridium] scindens |
7beta-HSDH | - |
Collinsella aerofaciens |
7beta-hydroxysteroid dehydrogenase | - |
Clostridium sardiniense |
7beta-hydroxysteroid dehydrogenase | - |
Paeniclostridium sordellii |
7beta-hydroxysteroid dehydrogenase | - |
Fusarium equiseti |
7beta-hydroxysteroid dehydrogenase | - |
[Clostridium] scindens |
7beta-hydroxysteroid dehydrogenase | - |
Collinsella aerofaciens |
RUMGNA_02585 | - |
Fusarium equiseti |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | NADP+-dependent | Clostridium sardiniense | |
NADP+ | NADP+-dependent | Paeniclostridium sordellii | |
NADP+ | NADP+-dependent | Fusarium equiseti | |
NADP+ | NADP+-dependent | [Clostridium] scindens | |
NADP+ | NADP+-dependent | Collinsella aerofaciens |