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Literature summary for 1.1.1.201 extracted from

  • Macdonald, I.A.; Rochon, Y.P.; Hutchinson, D.M.; Holdeman, L.V.
    Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7alpha-hydroxysteroid dehydrogenase-elaborating organisms (1982), Appl. Environ. Microbiol., 44, 1187-1195.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+ Collinsella aerofaciens partially reversible, poor substrate 3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
-
r
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+ Collinsella aerofaciens ursocholic acid 3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
-
r
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+ Collinsella aerofaciens ursodeoxycholic acid 3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
-
r
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+ Collinsella aerofaciens partially reversible 3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
-
r
3alpha,7beta-dihydroxy-5beta-cholanoyl taurine + NADP+ Collinsella aerofaciens partially reversible, poore substrate 3alpha-hydroxy-7-keto-5beta-cholanoyl taurine + NADPH
-
r

Organism

Organism UniProt Comment Textmining
Collinsella aerofaciens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Collinsella aerofaciens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+ partially reversible, poor substrate Collinsella aerofaciens 3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
-
r
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+ ursocholic acid Collinsella aerofaciens 3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
-
r
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+ ursodeoxycholic acid Collinsella aerofaciens 3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
-
r
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+ partially reversible Collinsella aerofaciens 3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
-
r
3alpha,7beta-dihydroxy-5beta-cholanoyl taurine + NADP+ partially reversible, poore substrate Collinsella aerofaciens 3alpha-hydroxy-7-keto-5beta-cholanoyl taurine + NADPH
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.8 10.3
-
Collinsella aerofaciens

Cofactor

Cofactor Comment Organism Structure
NADP+ no activity with NAD+ Collinsella aerofaciens