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Literature summary for 1.1.1.2 extracted from

  • Barski, O.A.; Papusha, V.Z.; Ivanova, M.M.; Rudman, D.M.; Finegold, M.J.
    Developmental expression and function of aldehyde reductase in proximal tubules of the kidney (2005), Am. J. Physiol. Renal Physiol., 289, F200-F207.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
AL-1576 0.5 microM, (10 x KI), 13fold higher affinity for aldehyde reductase than for aldose reductase; 0.5 microM, (10 x KI), 13fold higher affinity for aldehyde reductase than for aldose reductase, reversible Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
apical plasma membrane proximal tubules, high concentration Mus musculus 16324
-
cytosol low concentration Mus musculus 5829
-
membrane proximal tubules Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucuronate + NADPH Mus musculus
-
?
-
?
glucuronate + NADPH Mus musculus C57BL/6
-
?
-
?
glucuronate + NADPH + H+ Mus musculus
-
?
-
?
glucuronate + NADPH + H+ Mus musculus C57BL/6
-
?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JII6
-
-
Mus musculus Q9JII6 C57BL/6
-
Mus musculus C57BL/6 Q9JII6 C57BL/6
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Mus musculus
-
kidney fetal kidney, 10fold higher enzymatic activity observed compared with other tissues Mus musculus
-
kidney cortex represents as much as 1% of total cytosolic protein in the kidney Mus musculus
-
liver
-
Mus musculus
-
stomach
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
10fold higher enzymatic activity observed in kidney compared with other tissues, enzyme activity depends on the human´s age Mus musculus
additional information
-
10fold higher enzymatic activity observed in kindney compare with other tissues, enzyme activity depends on the animal’s age, activity approaches a plateau by day 35 and does not differ between male and female mice Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucuronate + NADPH 0.1 M phosphat buffer, pH 7.0 Mus musculus ?
-
?
D-glucuronate + NADPH 0.1 M phosphat buffer, pH 7.0 Mus musculus C57BL/6 ?
-
?
D-glucuronate + NADPH + H+ 0.1 M phosphate buffer, pH 7.0 Mus musculus ?
-
?
D-glucuronate + NADPH + H+ 0.1 M phosphate buffer, pH 7.0 Mus musculus C57BL/6 ?
-
?
glucuronate + NADPH
-
Mus musculus ?
-
?
glucuronate + NADPH
-
Mus musculus C57BL/6 ?
-
?
glucuronate + NADPH + H+
-
Mus musculus ?
-
?
glucuronate + NADPH + H+
-
Mus musculus C57BL/6 ?
-
?

Synonyms

Synonyms Comment Organism
AKR1A1
-
Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay pH Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
7
-
assay pH Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
AL-1576
-
Mus musculus