Protein Variants | Comment | Organism |
---|---|---|
additional information | gene deletion mutant and combined gene deletion mutant lacking both ADH and ADH7, both are viable and show similar growth curves as wild-type | Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.011 | - |
NADPH | pH 7.0, 25°C | Saccharomyces cerevisiae | |
0.013 | - |
NADP+ | pH 10.0, 25°C | Saccharomyces cerevisiae | |
0.029 | - |
NADPH | pH 7.0, 25°C | Saccharomyces cerevisiae | |
0.043 | - |
cinnamaldehyde | pH 7.0, 25°C | Saccharomyces cerevisiae | |
0.048 | - |
3-Methylbutanal | pH 7.0, 25°C | Saccharomyces cerevisiae | |
0.049 | - |
pentanal | pH 7.0, 25°C | Saccharomyces cerevisiae | |
0.058 | - |
veratraldehyde | pH 7.0, 25°C | Saccharomyces cerevisiae | |
0.06 | - |
pentanal | pH 7.0, 25°C | Saccharomyces cerevisiae | |
0.061 | - |
NADP+ | pH 10.0, 25°C | Saccharomyces cerevisiae | |
0.073 | - |
veratraldehyde | pH 7.0, 25°C | Saccharomyces cerevisiae | |
0.08 | - |
cinnamyl alcohol | pH 10.0, 25°C | Saccharomyces cerevisiae | |
0.11 | - |
cinnamyl alcohol | pH 7.0, 25°C | Saccharomyces cerevisiae | |
0.129 | - |
3-Methylbutanal | pH 7.0, 25°C | Saccharomyces cerevisiae | |
0.152 | - |
hexanal | pH 7.0, 25°C | Saccharomyces cerevisiae | |
0.172 | - |
cinnamaldehyde | pH 7.0, 25°C | Saccharomyces cerevisiae | |
0.436 | - |
cinnamyl alcohol | pH 7.0, 25°C | Saccharomyces cerevisiae | |
0.7 | - |
cinnamyl alcohol | pH 10.0, 25°C | Saccharomyces cerevisiae | |
0.99 | - |
1-Pentanol | pH 10.0, 25°C | Saccharomyces cerevisiae | |
1.61 | - |
3-methyl-1-butanol | pH 10.0, 25°C | Saccharomyces cerevisiae | |
2.2 | - |
Phenylethanol | pH 10.0, 25°C | Saccharomyces cerevisiae | |
4.6 | - |
3-methyl-1-butanol | pH 7.0, 25°C | Saccharomyces cerevisiae | |
9.1 | - |
Hexanol | pH 7.0, 25°C | Saccharomyces cerevisiae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
2 * 40000, SDS-PAGE | Saccharomyces cerevisiae |
71000 | - |
gel filtration | Saccharomyces cerevisiae |
81000 | - |
gel filtration | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Saccharomyces cerevisiae | - |
ADH7 | - |
Purification (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
90 | - |
pH 7.0, 25°C | Saccharomyces cerevisiae |
183 | - |
25°C, pH 7.0 | Saccharomyces cerevisiae |
Storage Stability | Organism |
---|---|
-20°C, 20% v/v glycerol, stable for at least one month | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E)-4-hydroxynon-2-enal + NADPH | 30% of activity with cinnamaldehyde | Saccharomyces cerevisiae | (2E)-non-2-ene-1,4-diol + NADP+ | - |
r | |
(2S)-methyl-1-butanol + NADP+ | 39% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | (2S)-methylbutanal + NADPH | - |
r | |
1-butanol + NADP+ | 42% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | butanal + NADPH | - |
r | |
1-hexanol + NADP+ | 45% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | hexanal + NADPH | - |
r | |
1-octanol + NADP+ | 30% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | octanal + NADPH | - |
r | |
1-pentanol + NADP+ | 46% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | pentanal + NADPH | - |
r | |
1-propanol + NADP+ | 16% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | propanal + NADPH | - |
r | |
2-(S)-methylbutanol + NADP+ | 7% of activity with cinnamyl alcohol | Saccharomyces cerevisiae | (2S)-2-methylbutanal + NADPH | - |
r | |
2-butanol + NADP+ | 2% of activity with cinnamyl alcohol | Saccharomyces cerevisiae | 2-butanone + NADPH | - |
r | |
2-butanol + NADP+ | 1% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | butanone + NADPH | - |
r | |
2-methyl-1-propanol + NADP+ | 28% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | 2-methylpropanal + NADPH | - |
r | |
2-methylbutanal + NADPH | 89% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | 2-methyl-1-butanol + NADP+ | - |
r | |
2-methylbutanal + NADPH | 92% of activity with cinnamaldehyde | Saccharomyces cerevisiae | 2-methyl-1-butanol + NADP+ | - |
r | |
2-methylpropanal + NADPH | 63% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | 2-methyl-1-propanol + NADP+ | - |
r | |
2-methylpropanal + NADPH | 67% of activity with cinnamaldehyde | Saccharomyces cerevisiae | 2-methyl-1-propanol + NADP+ | - |
r | |
2-methylpropanol + NADP+ | 1% of activity with cinnamyl alcohol | Saccharomyces cerevisiae | 2-methylpropanal + NADPH | - |
r | |
2-phenylethanol + NADP+ | 23% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | phenylacetaldehyde + NADPH | - |
r | |
3-methyl-1-butanol + NADP+ | 40% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | 3-methylbutanal + NADPH | - |
r | |
3-methylbutanal + NADPH | 79% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | 3-methyl-1-butanol + NADP+ | - |
r | |
3-methylbutanal + NADPH + H+ | 84% of activity with cinnamaldehyde | Saccharomyces cerevisiae | 3-methyl-1-butanol + NADP+ | - |
r | |
3-methylbutanol + NADP+ | 15% of activity with cinnamyl alcohol | Saccharomyces cerevisiae | 3-methylbutanal + NADPH | - |
r | |
anisaldehyde + NADPH | 72% of activity with cinnamaldehyde | Saccharomyces cerevisiae | 4-methoxybenzyl alcohol + NADP+ | - |
r | |
anisaldehyde + NADPH | 83% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | 4-methoxybenzyl alcohol + NADP+ | - |
r | |
benzaldehyde + NADPH | 45% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | benzyl alcohol + NADP+ | - |
r | |
benzaldehyde + NADPH | 72% of activity with cinnamaldehyde | Saccharomyces cerevisiae | benzyl alcohol + NADP+ | - |
r | |
benzyl alcohol + NADP+ | 45% of activity with cinnamyl alcohol | Saccharomyces cerevisiae | benzaldehyde + NADPH | - |
r | |
benzyl alcohol + NADP+ | 78% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | benzaldehyde + NADPH | - |
r | |
butanal + NADPH + H+ | 19% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | 1-butanol + NADP+ | - |
r | |
butanal + NADPH + H+ | 57% of activity with cinnamaldehyde | Saccharomyces cerevisiae | 1-butanol + NADP+ | - |
r | |
butane-1,2-diol + NADP+ | 2% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | butanal-2-ol + NADPH | - |
r | |
butane-1,3-diol + NADP+ | 5% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | butanal-3-ol + NADPH | - |
r | |
butane-1,4-diol + NADP+ | 8% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | butanal-4-ol + NADPH | - |
r | |
butanol + NADP+ | 24% of activity with cinnamyl alcohol | Saccharomyces cerevisiae | butanal + NADPH | - |
r | |
cinnamaldehyde + NADPH | - |
Saccharomyces cerevisiae | cinnamyl alcohol + NADP+ | - |
r | |
cinnamyl alcohol + NADP+ | - |
Saccharomyces cerevisiae | cinnamaldehyde + NADPH | - |
r | |
coniferaldehyde + NADPH | 10% of activity with cinnamaldehyde | Saccharomyces cerevisiae | coniferyl alcohol + NADP+ | - |
r | |
coniferaldehyde + NADPH | 15% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | coniferyl alcohol + NADP+ | - |
r | |
coniferyl alcohol + NADP+ | 27% of activity with cinnamyl alcohol | Saccharomyces cerevisiae | coniferylaldehyde + NADPH + H+ | - |
r | |
coniferyl alcohol + NADP+ | 7% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | coniferaldehyde + NADPH + H+ | - |
r | |
ethanol + NADP+ | 2% activity compared to cinnamyl alcohol | Saccharomyces cerevisiae | acetaldehyde + NADPH + H+ | - |
r | |
ethanol + NADP+ | 4% of activity with cinnamyl alcohol | Saccharomyces cerevisiae | acetaldehyde + NADPH + H+ | - |
r | |
furfural + NADPH | 27% of activity with cinnamaldehyde | Saccharomyces cerevisiae | furfuryl alcohol + NADP+ | - |
r | |
furfural + NADPH | 54% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | furfuryl alcohol + NADP+ | - |
r | |
heptanal + NADPH | 86% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | 1-heptanol + NADP+ | - |
r | |
heptanal + NADPH | 88% of activity with cinnamaldehyde | Saccharomyces cerevisiae | 1-heptanol + NADP+ | - |
r | |
hexanal + NADPH + H+ | 88% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | 1-hexanol + NADP+ | - |
r | |
hexanal + NADPH + H+ | 89% of activity with cinnamaldehyde | Saccharomyces cerevisiae | 1-hexanol + NADP+ | - |
r | |
hexanol + NADP+ | 154% of activity with cinnamyl alcohol | Saccharomyces cerevisiae | hexanal + NADPH | - |
r | |
additional information | no subbstrate: acetone, methylglyoxal, cyclohexanone | Saccharomyces cerevisiae | ? | - |
? | |
octanal + NADPH + H+ | 59% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | 1-octanol + NADP+ | - |
r | |
octanal + NADPH + H+ | 84% of activity with cinnamaldehyde | Saccharomyces cerevisiae | 1-octanol + NADP+ | - |
r | |
octanol + NADP+ | 52% of activity with cinnamyl alcohol | Saccharomyces cerevisiae | octanal + NADPH | - |
r | |
pentanal + NADPH | 109% of activity with cinnamaldehyde | Saccharomyces cerevisiae | 1-pentanol + NADP+ | - |
r | |
pentanal + NADPH | 153% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | 1-pentanol + NADP+ | - |
r | |
pentanol + NADP+ | 89% of activity with cinnamyl alcohol | Saccharomyces cerevisiae | pentanal + NADPH | - |
r | |
phenylacetaldehyde + NADPH + H+ | 90% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | 2-phenylethanol + NADP+ | - |
r | |
propanal + NADPH + H+ | 21% of activity with cinnamaldehyde | Saccharomyces cerevisiae | 1-propanol + NADP+ | - |
r | |
propanal + NADPH + H+ | 24% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | 1-propanol + NADP+ | - |
r | |
propanol + NADP+ | 7% of activity with cinnamyl alcohol | Saccharomyces cerevisiae | propanal + NADPH | - |
r | |
sinapaldehyde + NADPH + H+ | 3% of activity with cinnamaldehyde | Saccharomyces cerevisiae | sinapyl alcohol + NADP+ | - |
r | |
trans-2-nonenal + NADPH | 33% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | trans-2-nonen-1-ol + NADP+ | - |
r | |
trans-2-nonenal + NADPH | 39% of activity with cinnamaldehyde | Saccharomyces cerevisiae | trans-2-nonenol + NADP+ | - |
r | |
vanillin + NADPH | 57% of activity with cinnamaldehyde | Saccharomyces cerevisiae | 4-hydroxy-3-methoxybenzyl alcohol + NADP+ | - |
r | |
vanillin + NADPH | 84% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | 4-hydroxy-3-methoxybenzyl alcohol + NADP+ | - |
r | |
veratraldehyde + NADPH | 79% activity compared to cinnamaldehyde | Saccharomyces cerevisiae | 3,4-dimethoxybenzyl alcohol + NADP+ | - |
r | |
veratraldehyde + NADPH | 82% of activity with cinnamaldehyde | Saccharomyces cerevisiae | 3,4-dimethoxybenzyl alcohol + NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 40000, SDS-PAGE | Saccharomyces cerevisiae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
10.7 | - |
Hexanol | pH 7.0, 25°C | Saccharomyces cerevisiae | |
14.8 | - |
cinnamyl alcohol | pH 7.0, 25°C | Saccharomyces cerevisiae | |
70 | - |
cinnamyl alcohol | pH 10.0, 25°C | Saccharomyces cerevisiae | |
173 | - |
3-methyl-1-butanol | pH 7.0, 25°C | Saccharomyces cerevisiae | |
263 | - |
veratraldehyde | pH 7.0, 25°C | Saccharomyces cerevisiae | |
296 | - |
3-Methylbutanal | pH 7.0, 25°C | Saccharomyces cerevisiae | |
307 | - |
cinnamaldehyde | pH 7.0, 25°C | Saccharomyces cerevisiae | |
359 | - |
hexanal | pH 7.0, 25°C | Saccharomyces cerevisiae | |
378 | - |
pentanal | pH 7.0, 25°C | Saccharomyces cerevisiae | |
918 | - |
1-Pentanol | pH 10.0, 25°C | Saccharomyces cerevisiae | |
1132 | - |
Phenylethanol | pH 10.0, 25°C | Saccharomyces cerevisiae | |
1622 | - |
cinnamyl alcohol | pH 7.0, 25°C | Saccharomyces cerevisiae | |
2866 | - |
3-methyl-1-butanol | pH 10.0, 25°C | Saccharomyces cerevisiae | |
3404 | - |
cinnamyl alcohol | pH 10.0, 25°C | Saccharomyces cerevisiae | |
6000 | - |
veratraldehyde | pH 7.0, 25°C | Saccharomyces cerevisiae | |
7913 | - |
cinnamaldehyde | pH 7.0, 25°C | Saccharomyces cerevisiae | |
9581 | - |
3-Methylbutanal | pH 7.0, 25°C | Saccharomyces cerevisiae | |
11920 | - |
pentanal | pH 7.0, 25°C | Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
optimum for reduction reaction, assay of reduction and oxidation at | Saccharomyces cerevisiae |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 11 | oxidation reaction, increasing activity from pH 6.0 to 11.0 | Saccharomyces cerevisiae |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Saccharomyces cerevisiae | isoelectric focusing | - |
4.9 |
Saccharomyces cerevisiae | and 6.2, isoelectric focusing | - |
6 |
Saccharomyces cerevisiae | and 6.4, isoelectric focusing | - |
6 |