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Literature summary for 1.1.1.2 extracted from

  • Cash, C.; Maitre, M.; Mandel, P.
    Purification from human brain and some properties of two NADPH-linked aldehyde reductases which reduce succinic semialdehyde to 4-hydroxybutyrate (1979), J. Neurochem., 33, 1169-1175.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0026
-
 p-nitrobenzaldehyde low-Km reductase Rattus norvegicus
0.041
-
 p-nitrobenzaldehyde high-Km reductase Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
-
 Homo sapiens
90000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinic semialdehyde + NADPH + H+ Homo sapiens
-
 4-hydroxybutyrate + NADP+
-
 r
succinic semialdehyde + NADPH + H+ Rattus norvegicus
-
 4-hydroxybutyrate + NADP+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Rattus norvegicus
-
 rat
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydroxyphenylglycolaldehyde + NADPH low Km reductase Rattus norvegicus ? + NADP+
-
 r
p-nitrobenzaldehyde + NADPH
-
 Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
 ?
succinic semialdehyde + NADPH + H+
-
 Homo sapiens 4-hydroxybutyrate + NADP+
-
 r
succinic semialdehyde + NADPH + H+
-
 Rattus norvegicus 4-hydroxybutyrate + NADP+
-
 r

Subunits

Subunits Comment Organism
dimer
-
 Homo sapiens
monomer
-
 Rattus norvegicus
monomer 1 * 45000 Homo sapiens