Literature summary for 1.1.1.2 extracted from

Galamba, A.; Soetaert, K.; Buyssens, P.; Monnaie, D.; Jacobs, P.; Content, J.
Molecular and biochemical characterization of Mycobacterium smegmatis alcohol dehydrogenase C (2001), FEMS Microbiol. Lett., 196, 51-56.

Search for more literature for 1.1.1.2

Application

Application	Comment	Organism
medicine	enzyme as a target for anti-tuberculosis and other drugs	Mycolicibacterium smegmatis
medicine	enzyme as a target for anti-tuberculosis and other drugs	Mycobacterium leprae
medicine	enzyme as a target for anti-tuberculosis and other drugs	Mycobacterium tuberculosis
medicine	enzyme as a target for anti-tuberculosis and other drugs	Mycobacterium tuberculosis variant bovis
medicine	enzyme as a target for anti-tuberculosis and other drugs	Mycobacterium avium subsp. paratuberculosis
medicine	enzyme may be an interesting target for development of new anti-mycobacterial agents	Mycolicibacterium smegmatis

Cloned(Commentary)

Cloned (Comment)	Organism
gene encoding ADHC cloned and sequenced	Mycolicibacterium smegmatis
gene encoding NADP-dependent alcohol dehydrogenase cloned and sequenced	Mycobacterium tuberculosis variant bovis

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.03	-	octanal	-	Mycolicibacterium smegmatis
0.04	-	cinnamaldehyde	-	Mycolicibacterium smegmatis
0.053	-	benzaldehyde	-	Mycolicibacterium smegmatis
0.215	-	Butyraldehyde	-	Mycolicibacterium smegmatis
0.5	-	cinnamyl alcohol	-	Mycolicibacterium smegmatis

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
37100	-	calculated from amino acid sequence	Mycolicibacterium smegmatis
38000	-	SDS-PAGE	Mycolicibacterium smegmatis

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	-	-	-
Equus sp.	-	-	-
Escherichia coli	-	-	-
Helicobacter pylori	-	-	-
Mycobacterium avium	-	-	-
Mycobacterium avium subsp. paratuberculosis	-	-	-
Mycobacterium leprae	-	-	-
Mycobacterium tuberculosis	-	var. bovis BCG	-
Mycobacterium tuberculosis variant bovis	-	-	-
Mycolicibacterium smegmatis	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Mycolicibacterium smegmatis
-	Mycobacterium tuberculosis variant bovis

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Equus sp.	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.024	-	-	Mycolicibacterium smegmatis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzaldehyde + NADPH	-	Bacillus subtilis	benzyl alcohol + NADP+	-	r
benzaldehyde + NADPH	-	Mycolicibacterium smegmatis	benzyl alcohol + NADP+	-	r
benzaldehyde + NADPH	-	Mycobacterium avium	benzyl alcohol + NADP+	-	r
benzaldehyde + NADPH	-	Mycobacterium leprae	benzyl alcohol + NADP+	-	r
benzaldehyde + NADPH	-	Helicobacter pylori	benzyl alcohol + NADP+	-	r
benzaldehyde + NADPH	-	Mycobacterium tuberculosis variant bovis	benzyl alcohol + NADP+	-	r
benzaldehyde + NADPH	-	Mycobacterium avium subsp. paratuberculosis	benzyl alcohol + NADP+	-	r
cinnamyl alcohol + NADP+	-	Mycolicibacterium smegmatis	cinnamylaldehyde + NADPH	-	r
n-butyraldehyde + NADPH	-	Mycolicibacterium smegmatis	n-butanol + NADP+	-	r
n-octanal + NADPH + H+	-	Mycolicibacterium smegmatis	n-octanol + NADP+	-	r

Subunits

Subunits	Comment	Organism
dimer	-	Mycobacterium tuberculosis variant bovis

Synonyms

Synonyms	Comment	Organism
alcohol dehydrogenase C	-	Mycolicibacterium smegmatis

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Release 2023.1 (January 2023)