Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Li2SO4 | both aldehyde reductase I and II are susceptible to inhibition | Homo sapiens | |
NaCl | aldehyde reductase I and II | Homo sapiens | |
sorbinil | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
3-Pyridinecarboxaldehyde | AR I | Homo sapiens | |
0.02 | - |
NADPH | AR II | Homo sapiens | |
0.05 | - |
NADPH | AR I | Homo sapiens | |
0.07 | - |
glyceraldehyde | AR I | Homo sapiens | |
0.07 | - |
glyceraldehyde | aldehyde reductase I, at pH 7.3 and 37°C | Homo sapiens | |
0.21 | - |
propionaldehyde | AR I | Homo sapiens | |
2.53 | - |
glucuronate | AR II | Homo sapiens | |
2.63 | - |
propionaldehyde | AR II | Homo sapiens | |
6.67 | - |
glyceraldehyde | AR II | Homo sapiens | |
6.67 | - |
glyceraldehyde | aldehyde reductase II, at pH 7.0 and 37°C | Homo sapiens | |
8.61 | - |
3-Pyridinecarboxaldehyde | AR II | Homo sapiens | |
215 | - |
D-glucose | AR I | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32500 | - |
1 * 32500, SDS-PAGE | Homo sapiens |
32500 | - |
1 * 32500 + 1 * 39000 | Homo sapiens |
32700 | - |
aldehyde reductase II, gel filtration | Homo sapiens |
39000 | - |
1 * 32500 + 1 * 39000 | Homo sapiens |
74000 | - |
aldehyde reductase I, gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH | Cavia porcellus | - |
L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | Cavia porcellus | - |
glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | Homo sapiens | - |
glycerol + NADP+ | - |
r | |
L-glyceraldehyde + NADPH | Cavia porcellus | - |
glycerol + NADP+ | - |
r | |
L-glyceraldehyde + NADPH | Homo sapiens | - |
glycerol + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
guinea pig | - |
Homo sapiens | - |
human | - |
Purification (Comment) | Organism |
---|---|
aldehyde reductase I and II | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Cavia porcellus | - |
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-pyridinecarboxaldehyde + NADPH | - |
Cavia porcellus | 3-pyridinemethanol + NADP+ | - |
r | |
3-pyridinecarboxaldehyde + NADPH | - |
Homo sapiens | 3-pyridinemethanol + NADP+ | - |
r | |
D-glucose + NADPH | placenta aldehyde reductase I | Homo sapiens | ? + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Cavia porcellus | L-gulonate + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Cavia porcellus | L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | aldehyde reductase II | Homo sapiens | L-gulonate + NADP+ | - |
? | |
D-glyceraldehyde + NADPH + H+ | - |
Cavia porcellus | glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
L-glyceraldehyde + NADPH | - |
Cavia porcellus | glycerol + NADP+ | - |
r | |
L-glyceraldehyde + NADPH | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
propionaldehyde + NADPH | - |
Homo sapiens | propanol + NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 32500 + 1 * 39000 | Homo sapiens |
monomer | 1 * 32500, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
aldo-keto reductase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
aldehyde reductaseI | Homo sapiens |
7 | - |
aldehyde reductase II | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | aldehyde reductase I | Homo sapiens | |
NADPH | aldehyde reductase II utilizes only NADPH as cofactor | Homo sapiens |