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Literature summary for 1.1.1.2 extracted from
- Purification of the high-Km aldehyde reductase from rat brain and liver and from ox brain (1981), Biochem. J., 197, 473-481.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chlorpromazine | - |
Bos taurus |  |
| chlorpromazine | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | 0.005 | NADPH | - |
Rattus norvegicus | |
| 0.037 | - |
Succinic semialdehyde | - |
Cricetinae | |
| 0.08 | - |
p-nitrobenzaldehyde | - |
Rattus norvegicus | |
| 0.13 | - |
Succinic semialdehyde | - |
Rattus norvegicus | |
| 1.5 | - |
DL-glyceraldehyde | - |
Rattus norvegicus | |
| 4.5 | - |
D-glucuronate | - |
Rattus norvegicus | |
| 10.9 | - |
Succinic semialdehyde | liver enzyme | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30000 | 40000 | - |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucuronate + NADPH | Mus musculus | - |
L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | Rattus norvegicus | - |
L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | Bos taurus | - |
L-gulonate + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | Mus musculus | - |
glycerol + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | Homo sapiens | - |
glycerol + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | Rattus norvegicus | - |
glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | Mus musculus | - |
glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | Homo sapiens | - |
glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | Rattus norvegicus | - |
glycerol + NADP+ | - |
r | |
| L-gulonic acid + NADP+ | Rattus norvegicus | - |
D-glucuronic acid + NADPH | - |
r | |
| L-gulonic acid + NADP+ | Bos taurus | - |
D-glucuronic acid + NADPH | - |
r | |
| succinic semialdehyde + NADPH + H+ | Homo sapiens | - |
4-hydroxybutyrate + NADP+ | - |
r | |
| succinic semialdehyde + NADPH + H+ | Rattus norvegicus | - |
4-hydroxybutyrate + NADP+ | - |
r | |
| succinic semialdehyde + NADPH + H+ | Bos taurus | - |
4-hydroxybutyrate + NADP+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
ox | - |
| Cricetinae | - |
- |
- |
| Homo sapiens | - |
human | - |
| Mus musculus | - |
mouse | - |
| Rattus norvegicus | - |
rat | - |
| Rattus norvegicus | - |
Wistar albino | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| brain | - |
Cricetinae | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| liver | - |
Cricetinae | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 9.59 | - |
high-Km aldehyde reductase from brain | Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 0°C when stored frozen there is negligible loss of activity after 6 months, but repeated freezing and thawing results in loss of activity | Rattus norvegicus |
| 4°C loses activity only slowly over several weeks | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-pyridinecarboxaldehyde + NADPH | - |
Homo sapiens | 3-pyridinemethanol + NADP+ | - |
r | |
| 3-pyridinecarboxaldehyde + NADPH | - |
Rattus norvegicus | 3-pyridinemethanol + NADP+ | - |
r | |
| 3-pyridinecarboxaldehyde + NADPH | - |
Bos taurus | 3-pyridinemethanol + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Mus musculus | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Mus musculus | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Bos taurus | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Bos taurus | L-gulonate + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | - |
Mus musculus | glycerol + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus | glycerol + NADP+ | - |
r | |
| glycerol + NADP+ | - |
Rattus norvegicus | DL-glyceraldehyde + NADPH + H+ | - |
? | |
| L-glyceraldehyde + NADPH | - |
Mus musculus | glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | - |
Rattus norvegicus | glycerol + NADP+ | - |
r | |
| L-gulonic acid + NADP+ | - |
Rattus norvegicus | D-glucuronic acid + NADPH | - |
r | |
| L-gulonic acid + NADP+ | - |
Bos taurus | D-glucuronic acid + NADPH | - |
r | |
| L-gulonic acid + NADPH | - |
Rattus norvegicus | D-glucuronic acid + NADP+ | - |
r | |
| L-gulonic acid + NADPH | - |
Bos taurus | D-glucuronic acid + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Homo sapiens | p-nitrobenzylalcohol + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Rattus norvegicus | p-nitrobenzylalcohol + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Bos taurus | p-nitrobenzylalcohol + NADP+ | - |
r | |
| succinic semialdehyde + NADPH + H+ | - |
Homo sapiens | 4-hydroxybutyrate + NADP+ | - |
r | |
| succinic semialdehyde + NADPH + H+ | - |
Rattus norvegicus | 4-hydroxybutyrate + NADP+ | - |
r | |
| succinic semialdehyde + NADPH + H+ | - |
Bos taurus | 4-hydroxybutyrate + NADP+ | - |
r | |
| succinic semialdehyde + NADPH + H+ | - |
Cricetinae | 4-hydroxybutyrate + NADP+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Homo sapiens |
| monomer | - |
Rattus norvegicus |
| monomer | - |
Bos taurus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | 50 | at 40°C for 10 min enzyme retains about 90% of its activity towards D-glucuronate, after 10 min at 50% activity decreases to less than 5% | Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.8 | 8 | - |
Rattus norvegicus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 8 | - |
Rattus norvegicus |
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