Any feedback?
Literature summary for 1.1.1.2 extracted from
- Human liver aldehyde reductase: pH dependence of steady-state kinetic parameters (1991), Arch. Biochem. Biophys., 287, 329-336.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | daunorubicin, a cancer chemotherapeutic agent can be reduced by aldehyde reductase | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP-ribose | competitive inhibition | Homo sapiens |  |
| diethyldicarbonate | kidney aldehyde reductase | Homo sapiens | |
| NADP+ | competitive inhibition | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | Homo sapiens | - |
glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | Homo sapiens | - |
glycerol + NADP+ | - |
r | |
| succinic semialdehyde + NADPH + H+ | Homo sapiens | - |
4-hydroxybutyrate + NADP+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
| daunorubicin + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
| L-glyceraldehyde + NADPH | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
| mevaldate + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
| succinic semialdehyde + NADPH + H+ | - |
Homo sapiens | 4-hydroxybutyrate + NADP+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 3-acetylpyridine adenine dinucleotide phosphate | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
