Literature summary for 1.1.1.195 extracted from

Jourdes, M.; Cardenas, C.L.; Laskar, D.D.; Moinuddin, S.G.; Davin, L.B.; Lewis, N.G.
Plant cell walls are enfeebled when attempting to preserve native lignin configuration with poly-p-hydroxycinnamaldehydes: evolutionary implications (2007), Phytochemistry, 68, 1932-1956.

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Protein Variants

Protein Variants	Comment	Organism
additional information	in double mutant strain lacking the activities of isoforms cad-4 and cad-5, the material strength properties of the stem plant material are greatly diminished due to severe reductions in macromolecular lignin content. Initially the overall pattern of phenolic deposition in the mutant is very similar to wild-type. Shortly into the stage involving 8-O-4'-linkage formation, deposition is aborted. At this final stage, the double mutant retains a very limited ability to biosynthesize monolignols as evidenced by cleavage and release of ca. 4% of the monolignol-derived moieties relative to the lignin of the wild-type line. In addition, while small amounts of cleavable p-hydroxycinnamaldehyde-derived moieties are released, the overall frequency of monomer cleavable 8-O-4'-inter-unit linkages closely approximates that of wild-type for the equivalent level of lignin deposition	Arabidopsis thaliana

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	isoforms Cad-4, Cad-5	-

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Release 2023.1 (January 2023)