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Literature summary for 1.1.1.19 extracted from

  • Shinoda, M.; Mori, S.; Shintani, S.; Ishikura, S.; Hara, A.
    Inhibition of human aldehyde reductase by drugs for testing the function of liver and kidney (1999), Biol. Pharm. Bull., 22, 741-744.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Amaranth
-
Homo sapiens
haematin
-
Homo sapiens
additional information potent inhibitors, i.e. carboxylic and sulfonic acids, bind weakly to the free enzyme but strongly to the enzyme-NADP+-binary complex Homo sapiens
phenolsulfophthalein
-
Homo sapiens
Sulfobromophthalein
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucuronate + NADPH Homo sapiens
-
L-gulonate + NADP+
-
r
L-gulonate + NADP+ Homo sapiens
-
D-glucuronate + NADPH
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
r
L-gulonate + NADP+
-
Homo sapiens D-glucuronate + NADPH
-
r

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens