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Literature summary for 1.1.1.19 extracted from

  • Bublitz, C.; Lehninger, A.L.
    Ascorbic acid synthesis in animal tissue I. TPN-L-gulonate dehydrogenase (1963), Methods Enzymol., 6, 334-337.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
p-chloromercuribenzoate
-
Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucuronate + NADPH Sus scrofa formation of ascorbic acid L-gulonate + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Sus scrofa

Storage Stability

Storage Stability Organism
-5°C, 2 weeks Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-galacturonate + NADPH
-
Sus scrofa ?
-
r
D-glucuronate + NADPH formation of ascorbic acid Sus scrofa L-gulonate + NADP+
-
?
L-gulonate + NADP+
-
Sus scrofa D-glucuronate + NADPH
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.6 9.3
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Sus scrofa