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Literature summary for 1.1.1.189 extracted from

  • Lee, S.C.; Levine, L.
    Purification and regulatory properties of chicken heart prostaglandin E 9-ketoreductase (1975), J. Biol. Chem., 250, 4549-4555.
    View publication on PubMed
Search for more literature for 1.1.1.189

Activating Compound

Activating Compound Comment Organism Structure
angiotensin I at 0.1 mM concentration Gallus gallus
ATP at 1mM concentration slight stimulation Gallus gallus
CTP at 1mM concentration slight stimulation Gallus gallus
GTP at 1mM concentration slight stimulation Gallus gallus
Sodium diphosphate
-
 Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoate) complete inhibition at 1 mM concentration Gallus gallus
p-chloromercuribenzoate complete inhibition at 1 mM concentration Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000 55000 gel filtration Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.73
-
-
 Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
 Gallus gallus (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Gallus gallus
7.4 8.8
-
 Gallus gallus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Gallus gallus