Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.189 extracted from

  • Thuy, L.P.; Carpenter, M.P.
    Prostaglandin E2-9-ketoreductase from rat testis (1978), Biochem. Biophys. Res. Commun., 81, 322-328.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cu2+ 5 mM concentration Rattus norvegicus
FAD 5 mM concentration Rattus norvegicus
additional information no effect: Mg2+, Ca2+, EDTA, EGTA, cAMP and cGMP Rattus norvegicus
NAD+ 5 mM concentration 60% inhibition, competitive Rattus norvegicus
NADP+ 5 mM concentration 60% inhibition, non-competitive Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
Rattus norvegicus (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
100
-
no activity after heating at 100°C for 3 min Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8.5
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus
NADH 30% less effective than NADPH Rattus norvegicus
NADPH
-
Rattus norvegicus