Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.189 extracted from

  • Schieber, A.; Ghisla, S.
    Prostaglandin 9-ketoreductase from pig and human kidney: purification, properties and identity with human carbonyl reductase (1992), Eicosanoids, 5, S37-38.
    View publication on PubMed
Search for more literature for 1.1.1.189

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ 1.9 g-atoms per mol enzyme Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
 gel filtration, 4 isoforms Sus scrofa
34000
-
 gel filtration, 4 isoforms Homo sapiens
35000
-
 alpha, 1 * 35000, SDS-PAGE Sus scrofa

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-
kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NAD(P)+
-
 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H
-
 ?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NAD(P)+
-
 Sus scrofa (5Z,13E)-11alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H
-
 ir
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
 Homo sapiens (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
 r
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ enzyme is pro(S) stereo selective with regard to hydrogen transfer from NADPH Sus scrofa (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
 r
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
 Homo sapiens (5Z,13E)-9alpha,11alpha-dihydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+
-
 ?
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
 Sus scrofa (5Z,13E)-9alpha,11alpha-dihydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+
-
 ir
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+
-
 Homo sapiens (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH
-
 ?
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+
-
 Sus scrofa (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH
-
 ir

Subunits

Subunits Comment Organism
monomer alpha, 1 * 34000, SDS-PAGE Homo sapiens
monomer alpha, 1 * 35000, SDS-PAGE Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NAD+ preferential 15-keto prostaglandin F2alpha formation Sus scrofa
NADPH
-
 Homo sapiens
NADPH
-
 Sus scrofa