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Literature summary for 1.1.1.189 extracted from

  • Asselin, E.; Fortier, M.A.
    Detection and regulation of the messenger for a putative bovine endometrial 9-keto-prostaglandin E2 reductase: effect of oxytocin and interferon-tau (2000), Biol. Reprod., 62, 125-131.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
interferon tau recombinant ovine interferon tau stimulates significantly prostaglandin E2 and prostaglandin F2alpha production at a concentration of 0.01 mg per ml Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
interferon tau recombinant ovine interferon tau inhibits 25% prostaglandin E2 and prostaglandin F2alpha production at a concentration of 1 ng per ml Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ Bos taurus together with PGF synthase this enzyme can be a key enzyme in the regulation of specific prostaglandines in the endometrium during the preimplantation period (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
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Organism

Organism UniProt Comment Textmining
Bos taurus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium endometrial Bos taurus
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kidney
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Bos taurus
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liver highest mRNA concentration Bos taurus
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ovary
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Bos taurus
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testis
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Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
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Bos taurus (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
?
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ together with PGF synthase this enzyme can be a key enzyme in the regulation of specific prostaglandines in the endometrium during the preimplantation period Bos taurus (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
?