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Literature summary for 1.1.1.188 extracted from

  • Yang, W.; Ni, J.; Woodward, D.F.; Tang-Liu, D.D.; Ling, K.H.
    Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2 (2005), J. Lipid Res., 46, 2745-2751.
    View publication on PubMed

Application

Application Comment Organism
synthesis development of a coupled assay method for enzymatic formation of prostamide F2alpha from anandamide by the cyclooxygenase-II and the prostaglandin synthase F involving the intermediate metabolite, prostamide H2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prostaglandin D2 + NADPH + H+ reaction via formation of the endoperoxide ethanolamide intermediate prostaglandin H2 Homo sapiens 9alpha,11alpha-prostaglandin F2alpha + NADP+
-
?
prostamide H2 + NADPH + H+ about 70% of prostamide H2 is converted to prostamide F2alpha after 2 min at 37°C Homo sapiens prostamide F2alpha + NADP+
-
?

Synonyms

Synonyms Comment Organism
PGF synthase
-
Homo sapiens
PGFS
-
Homo sapiens
prostaglandin F synthase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens