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Literature summary for 1.1.1.184 extracted from

  • Akita, H.; Watanabe, M.; Suzuki, T.; Nakashima, N.; Hoshino, T.
    Molecular cloning and characterization of two YGL039w genes encoding broad specificity NADPH-dependent aldehyde reductases from Kluyveromyces marxianus strain DMB1 (2015), FEMS Microbiol. Lett., 362, pii: fnv116.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Kluyveromyces marxianus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.028
-
NADPH pH 6.0, 25°C Kluyveromyces marxianus
0.034
-
NADPH pH 6.0, 25°C Kluyveromyces marxianus
0.43
-
methyl glyoxal pH 6.0, 25°C Kluyveromyces marxianus
1.6
-
methyl glyoxal pH 6.0, 25°C Kluyveromyces marxianus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35800
-
gel filtration Kluyveromyces marxianus
36900
-
gel filtration Kluyveromyces marxianus
37000
-
1 * 37000, SDS-PAGE Kluyveromyces marxianus

Organism

Organism UniProt Comment Textmining
Kluyveromyces marxianus A0A0E4AX59
-
-
Kluyveromyces marxianus A0A0E4AY21
-
-
Kluyveromyces marxianus DMB1 A0A0E4AX59
-
-
Kluyveromyces marxianus DMB1 A0A0E4AY21
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.58
-
substrate benzaldehyde, pH 6.0, 25°C Kluyveromyces marxianus
0.6
-
substrate benzaldehyde, pH 6.0, 25°C Kluyveromyces marxianus
0.65
-
substrate furfural, pH 6.0, 25°C Kluyveromyces marxianus
0.96
-
substrate methyl glyoxal, pH 6.0, 25°C Kluyveromyces marxianus
1.1
-
substrate p-anisaldehyde, pH 6.0, 25°C Kluyveromyces marxianus
1.2
-
substrate furfural, pH 6.0, 25°C Kluyveromyces marxianus
1.5
-
substrate hexanal, pH 6.0, 25°C Kluyveromyces marxianus
2
-
substrate hexanal, pH 6.0, 25°C Kluyveromyces marxianus
2.1
-
substrate octanal, pH 6.0, 25°C Kluyveromyces marxianus
2.1
-
substrate valeraldehyde, pH 6.0, 25°C Kluyveromyces marxianus
3
-
substrate heptanal, pH 6.0, 25°C Kluyveromyces marxianus
3.2
-
substrate methyl glyoxal, pH 6.0, 25°C Kluyveromyces marxianus
3.3
-
substrate isovaleraldehyde, pH 6.0, 25°C Kluyveromyces marxianus
4.2
-
substrate isovaleraldehyde, pH 6.0, 25°C Kluyveromyces marxianus
4.5
-
substrate p-anisaldehyde, pH 6.0, 25°C Kluyveromyces marxianus
5.3
-
substrate octanal, pH 6.0, 25°C Kluyveromyces marxianus
5.9
-
substrate valeraldehyde, pH 6.0, 25°C Kluyveromyces marxianus
6.9
-
substrate heptanal, pH 6.0, 25°C Kluyveromyces marxianus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzaldehyde + NADPH + H+
-
Kluyveromyces marxianus benzyl alcohol + NADP+
-
?
benzaldehyde + NADPH + H+
-
Kluyveromyces marxianus DMB1 benzyl alcohol + NADP+
-
?
furfural + NADPH + H+
-
Kluyveromyces marxianus furfuryl alcohol + NADP+
-
?
heptanal + NADPH + H+
-
Kluyveromyces marxianus heptan-1-ol + NADP+
-
?
heptanal + NADPH + H+
-
Kluyveromyces marxianus DMB1 heptan-1-ol + NADP+
-
?
hexanal + NADPH + H+
-
Kluyveromyces marxianus hexan-1-ol + NADP+
-
?
isovaleraldehyde + NADPH + H+
-
Kluyveromyces marxianus isoamyl alcohol + NADP+
-
?
isovaleraldehyde + NADPH + H+
-
Kluyveromyces marxianus DMB1 isoamyl alcohol + NADP+
-
?
methyl glyoxal + NADPH + H+
-
Kluyveromyces marxianus ? + NADP+
-
?
methyl glyoxal + NADPH + H+
-
Kluyveromyces marxianus DMB1 ? + NADP+
-
?
additional information strong activities are observed toward linear aldehydes, such as 1-heptanal, valeraldehyde and 1-octanal, but no activity toward 5-hydroxymethylfurfural, propionaldehyde, D-alanine, L-alanine,D-lactate, L-lactate or pyruvate. Enzyme does not exhibit NADP+-dependent oxidative activity toward corresponding alcohol analogs, including 1-hexanol, 1-heptanol, isoamyl alcohol, isobutanol, 1-octanol and 2-propanol Kluyveromyces marxianus ?
-
?
additional information strong activities are observed toward linear aldehydes, such as 1-heptanal, valeraldehyde and 1-octanal, but no activity toward HMF, propionaldehyde, D-alanine, L-alanine,D-lactate, L-lactate or pyruvate. Enzyme does not exhibit NADP+-dependent oxidative activity toward corresponding alcohol analogs, including 1-hexanol, 1-heptanol, isoamyl alcohol, isobutanol, 1-octanol and 2-propanol Kluyveromyces marxianus ?
-
?
additional information strong activities are observed toward linear aldehydes, such as 1-heptanal, valeraldehyde and 1-octanal, but no activity toward 5-hydroxymethylfurfural, propionaldehyde, D-alanine, L-alanine,D-lactate, L-lactate or pyruvate. Enzyme does not exhibit NADP+-dependent oxidative activity toward corresponding alcohol analogs, including 1-hexanol, 1-heptanol, isoamyl alcohol, isobutanol, 1-octanol and 2-propanol Kluyveromyces marxianus DMB1 ?
-
?
additional information strong activities are observed toward linear aldehydes, such as 1-heptanal, valeraldehyde and 1-octanal, but no activity toward HMF, propionaldehyde, D-alanine, L-alanine,D-lactate, L-lactate or pyruvate. Enzyme does not exhibit NADP+-dependent oxidative activity toward corresponding alcohol analogs, including 1-hexanol, 1-heptanol, isoamyl alcohol, isobutanol, 1-octanol and 2-propanol Kluyveromyces marxianus DMB1 ?
-
?
octanal + NADPH + H+
-
Kluyveromyces marxianus octan-1-ol + NADP+
-
?
p-anisaldehyde + NADPH + H+
-
Kluyveromyces marxianus p-anisalcohol + NADP+
-
?
valeraldehyde + NADPH + H+
-
Kluyveromyces marxianus pentan-1-ol + NADP+
-
?

Subunits

Subunits Comment Organism
monomer 1 * 37000, SDS-PAGE Kluyveromyces marxianus

Synonyms

Synonyms Comment Organism
YGL039w1
-
Kluyveromyces marxianus
YGL039w2
-
Kluyveromyces marxianus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
45 50
-
Kluyveromyces marxianus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
20 min, loss of more than 50% of activity Kluyveromyces marxianus
47
-
melting temperature Kluyveromyces marxianus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.5
-
methyl glyoxal pH 6.0, 25°C Kluyveromyces marxianus
2.67
-
NADPH pH 6.0, 25°C Kluyveromyces marxianus
3.67
-
NADPH pH 6.0, 25°C Kluyveromyces marxianus
4
-
methyl glyoxal pH 6.0, 25°C Kluyveromyces marxianus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
-
Kluyveromyces marxianus

Cofactor

Cofactor Comment Organism Structure
additional information no activity with NADH Kluyveromyces marxianus
NADPH exclusive use of NADPH Kluyveromyces marxianus