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Literature summary for 1.1.1.184 extracted from

  • Hou, H.; Li, R.; Wang, X.; Yuan, Z.; Liu, X.; Chen, Z.; Xu, X.
    Crystallographic analysis of a novel aldo-keto reductase from Thermotoga maritima in complex with NADP+ (2015), Acta Crystallogr. Sect. F, 71, 847-855.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Thermotoga maritima

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with cofactor NADP+ and with NADP+ and substrate ethyl 2-oxo-4-phenylbutyrate, to 1.7 and 2.0 A resolution, respectively. Both crystals belong to space group P3121, with similar unit-cell parameters Thermotoga maritima

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
x * 35000, SDS-PAGE, x * 35032, calculated Thermotoga maritima
35032
-
x * 35000, SDS-PAGE, x * 35032, calculated Thermotoga maritima

Organism

Organism UniProt Comment Textmining
Thermotoga maritima Q9X265
-
-
Thermotoga maritima DSM 3109 Q9X265
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ethyl 2-oxo-4-phenylbutyrate + NADPH + H+
-
Thermotoga maritima ethyl 2-hydroxy-4-phenylbutyrate + NADP+
-
?
ethyl 2-oxo-4-phenylbutyrate + NADPH + H+
-
Thermotoga maritima DSM 3109 ethyl 2-hydroxy-4-phenylbutyrate + NADP+
-
?

Subunits

Subunits Comment Organism
? x * 35000, SDS-PAGE, x * 35032, calculated Thermotoga maritima

Synonyms

Synonyms Comment Organism
Tm_1743
-
Thermotoga maritima

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
60
-
-
Thermotoga maritima

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Thermotoga maritima