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Literature summary for 1.1.1.184 extracted from

  • Zimmermann, T.; Niesen, F.; Pilka, E.; Knapp, S.; Oppermann, U.; Maier, M.
    Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone (2009), Bioorg. Med. Chem., 17, 530-536.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
14,16-dihydroxy-3,8-dimethyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione zearalenone analogue Homo sapiens
Biochanin A
-
Homo sapiens
chrysin
-
Homo sapiens
naringenin
-
Homo sapiens
triclosan
-
Homo sapiens
wedelolactone
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
carbonyl reductase 1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isatin + NADPH + H+
-
Homo sapiens 3-hydroxy-2-oxoindole + NADP+
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00004
-
14,16-dihydroxy-3,8-dimethyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione pH 6.9, temperature not specified in the publication Homo sapiens
0.00006
-
triclosan pH 6.9, temperature not specified in the publication Homo sapiens
0.00011
-
chrysin pH 6.9, temperature not specified in the publication Homo sapiens
0.00052
-
radiciol pH 6.9, temperature not specified in the publication Homo sapiens
0.0006
-
wedelolactone pH 6.9, temperature not specified in the publication Homo sapiens
0.00203
-
Biochanin A pH 6.9, temperature not specified in the publication Homo sapiens
0.00343
-
naringenin pH 6.9, temperature not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00021
-
pH 6.9, temperature not specified in the publication Homo sapiens 14,16-dihydroxy-3,8-dimethyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione
0.0004
-
pH 6.9, temperature not specified in the publication Homo sapiens triclosan
0.00067
-
pH 6.9, temperature not specified in the publication Homo sapiens chrysin
0.00327
-
pH 6.9, temperature not specified in the publication Homo sapiens radiciol
0.00378
-
pH 6.9, temperature not specified in the publication Homo sapiens wedelolactone
0.0127
-
pH 6.9, temperature not specified in the publication Homo sapiens Biochanin A
0.0215
-
pH 6.9, temperature not specified in the publication Homo sapiens naringenin