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Literature summary for 1.1.1.184 extracted from
- Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones (2007), J. Enzyme Inhib. Med. Chem., 22, 105-109.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| butyrophenone | inhibitory potency in decreasing order: hexanophenone, valerophenone, heptanophenone, butyrophenone, propiophenone | Sus scrofa |  |
| heptanophenone | inhibitory potency in decreasing order: hexanophenone, valerophenone, heptanophenone, butyrophenone, propiophenone | Sus scrofa | |
| hexanophenone | competitive. Inhibitory potency in decreasing order: hexanophenone, valerophenone, heptanophenone, butyrophenone, propiophenone | Sus scrofa | |
| propiophenone | inhibitory potency in decreasing order: hexanophenone, valerophenone, heptanophenone, butyrophenone, propiophenone | Sus scrofa | |
| valerophenone | inhibitory potency in decreasing order: hexanophenone, valerophenone, heptanophenone, butyrophenone, propiophenone | Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.037 | - |
hexanophenone | pH 6.0, 37°C | Sus scrofa | |
| 0.048 | - |
valerophenone | pH 6.0, 37°C | Sus scrofa | |
| 0.078 | - |
heptanophenone | pH 6.0, 37°C | Sus scrofa | |
| 0.084 | - |
butyrophenone | pH 6.0, 37°C | Sus scrofa | |
| 0.249 | - |
propiophenone | pH 6.0, 37°C | Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Sus scrofa | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-benzoylpyridine + NADPH + H+ | - |
Sus scrofa | (S)-alpha-phenyl-4-pyridylmethanol + NADP+ | - |
? | |
| butyrophenone + NADPH | - |
Sus scrofa | 1-phenylbutan-1-ol + NADP+ | - |
? | |
| heptanophenone + NADPH | - |
Sus scrofa | 1-phenylheptan-1-ol + NADP+ | - |
? | |
| hexanophenone + NADPH | - |
Sus scrofa | 1-phenylhexan-1-ol + NADP+ | - |
? | |
| propiophenone + NADPH | - |
Sus scrofa | 1-phenylpropan-1-ol + NADP+ | - |
? | |
| valerophenone + NADPH | - |
Sus scrofa | 1-phenylpentan-1-ol + NADP+ | - |
? | |
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Release 2023.1 (January 2023)
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