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Literature summary for 1.1.1.184 extracted from

  • Oginuma, M.; Shimada, H.; Imamura, Y.
    Involvement of carbonyl reductase in superoxide formation through redox cycling of adrenochrome and 9,10-phenanthrenequinone in pig heart (2005), Chem. Biol. Interact., 155, 148-154.
    View publication on PubMed
Search for more literature for 1.1.1.184

Inhibitors

Inhibitors Comment Organism Structure
9,10-phenanthroline strong inhibition Sus scrofa
additional information adrenochrome is a poor inhibitor Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Sus scrofa
0.003
-
 9,10-phenanthroline pH 5.5, 37°C Sus scrofa
0.083
-
 Adrenochrome pH 6.0, 37°C Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Sus scrofa 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-benzoylpyridine + NADPH + H+ Sus scrofa stereoselective reduction S-(-)-phenylpyridin-4-yl-methynol + NADP+
-
 ?
all-trans retinal + NADPH + H+ Sus scrofa
-
 all-trans retinol + NADP+
-
 ?
additional information Sus scrofa the enzyme plays a role in superoxide formation through redox cycling of 9,10-phenanthrenequinone and, to a lesser extent, of adrenochrome in pig heart ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-benzoylpyridine + NADPH + H+ stereoselective reduction Sus scrofa S-(-)-phenylpyridin-4-yl-methynol + NADP+
-
 ?
9,10-phenanthroline + NADPH + H+ stereoselective reduction Sus scrofa ?
-
 ?
adrenochrome + NADPH + H+ stereoselective reduction Sus scrofa ?
-
 ?
all-trans retinal + NADPH + H+
-
 Sus scrofa all-trans retinol + NADP+
-
 ?
additional information the enzyme plays a role in superoxide formation through redox cycling of 9,10-phenanthrenequinone and, to a lesser extent, of adrenochrome in pig heart Sus scrofa ?
-
 ?

Synonyms

Synonyms Comment Organism
PHCR
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
 with 9,10-phenanthroline as substrate Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Sus scrofa