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Literature summary for 1.1.1.184 extracted from

  • Cha, J.H.; Pae, A.N.; Choi, K.I.; Cho, Y.S.; Kim, W.H.; Han, Y.S.; Yun, H.C.; Lee, J.; Koh, H.Y.; Lee, E.
    Stereochemical control in diastereoselective reduction of alpha-substituted-beta-ketoesters using a reductase purified from Kluyveromyces marxianus (2002), Biotechnol. Lett., 24, 1695-1698.
No PubMed abstract available

Organism

Organism UniProt Comment Textmining
Kluyveromyces marxianus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by several chromatographic steps, i.e. Q-Sepharose, FPLC, Phenyl Sepharose, HiTrap Blue, Red Sepharose, and gel filtration, and native PAGE Kluyveromyces marxianus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-(3,4,6-tri-[3,4,5,6-tetrahydro])phthalimido-ethyl-3-oxobutanoate + NADPH + H+
-
Kluyveromyces marxianus ethyl (3R)-2-[(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)methyl]-3-hydroxybutanoate + NADP+
-
?
2-(3,5-difluoro)phthalimido-ethyl-3-oxobutanoate + NADPH + H+
-
Kluyveromyces marxianus ethyl (3R)-2-[(4,7-difluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3-hydroxybutanoate + NADP+
-
?
2-(3-fluoro)phthalimido-ethyl-3-oxobutanoate + NADPH + H+
-
Kluyveromyces marxianus ethyl (3R)-2-[(4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3-hydroxybutanoate + NADP+
-
?
2-(3-fluoro)phthalimido-methyl-3-oxobutanoate + NADPH + H+
-
Kluyveromyces marxianus methyl (3R)-2-[(4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3-hydroxybutanoate + NADP+
-
?
2-(3-methoxy)phthalimido-ethyl-3-oxobutanoate + NADPH + H+
-
Kluyveromyces marxianus ethyl (3R)-3-hydroxy-2-[(4-methoxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]butanoate + NADP+
-
?
2-(4-fluoro)phthalimido-ethyl-3-oxobutanoate + NADPH + H+
-
Kluyveromyces marxianus ethyl (3R)-2-[(5-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3-hydroxybutanoate + NADP+
-
?
2-(4-methyl)phthalimido-ethyl-3-oxobutanoate + NADPH + H+
-
Kluyveromyces marxianus ethyl (3R)-3-hydroxy-2-[(5-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]butanoate + NADP+
-
?
2-(4-methyl)phthalimido-methyl-3-oxobutanoate + NADPH + H+
-
Kluyveromyces marxianus methyl (3R)-3-hydroxy-2-[(5-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]butanoate + NADP+
-
?
2-(4-tert-butyl)phthalimido-ethyl-3-oxobutanoate + NADPH + H+
-
Kluyveromyces marxianus ethyl (3R)-2-[(5-tert-butyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3-hydroxybutanoate + NADP+
-
?
2-phthalimido-ethyl-3-oxobutanoate + NADPH + H+ reduction of the beta-keto group to stereospecifically give the (R)-alcohol Kluyveromyces marxianus ethyl (3R)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3-hydroxybutanoate + NADP+
-
?
additional information asymmetric reduction, anti- and syndiastereoselective reactions, overview, identification of products Kluyveromyces marxianus ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Kluyveromyces marxianus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
assay at Kluyveromyces marxianus

Cofactor

Cofactor Comment Organism Structure
NADPH dependent on Kluyveromyces marxianus