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Literature summary for 1.1.1.184 extracted from

  • Nishinaka, T.; Kinoshita, Y.; Terada, N.; Terada, T.; Mizoguchi, T.; Nishihara, T.
    Characterization of multiple forms of carbonyl reductase from chicken liver (1993), Enzyme, 46, 221-228.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Barbital
-
Gallus gallus
coumarin
-
Gallus gallus
CuCl2 only enzyme forms CR2, CR3 Gallus gallus
quercitrin
-
Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
2 * 24000, SDS-PAGE, enzyme form CR1 Gallus gallus
32000
-
gel filtration, enzyme forms CR2, CR3 Gallus gallus
48000
-
gel filtration, enzyme form CR1 Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
3 forms from liver: CR1, CR2, CR3 Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-benzoylpyridine + NADPH
-
Gallus gallus ?
-
?
4-nitrobenzaldehyde + NADPH
-
Gallus gallus 4-nitrobenzyl alcohol + NADP+
-
?
5alpha-androstane-3,17-dione + NADPH
-
Gallus gallus ?
-
?
5alpha-dihydrotestosterone + NADPH only enzyme form CR1 Gallus gallus ?
-
?
5beta-androstane-3,17-dione + NADPH only enzyme form CR1 Gallus gallus ?
-
?
5beta-dihydrotestosterone + NADPH only enzyme form CR1 Gallus gallus ?
-
?
9,10-phenanthrenequinone + NADPH
-
Gallus gallus ?
-
?
cyclohexanone + NADPH
-
Gallus gallus cyclohexanol + NADP+
-
?
menadione + NADPH
-
Gallus gallus ?
-
?
additional information NADH only acts as cofactor for enzyme form CR1 Gallus gallus ?
-
?
pyridine-3-aldehyde + NADPH
-
Gallus gallus ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 24000, SDS-PAGE, enzyme form CR1 Gallus gallus
monomer SDS-PAGE, enzyme forms CR2, CR3 Gallus gallus