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Literature summary for 1.1.1.18 extracted from
- Inositol dehydrogenase from the yeast Cryptococcus melibiosum (1973), Biochim. Biophys. Acta, 293, 295-303.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NADH | competitive inhibition with NAD+ as variable substrate, bi-bi mechanism | Myxozyma melibiosi |  |
| scyllo-inosose | non-competitive inhibition with myo-inositol as varied substrate, uncompetitive with NAD+ as variable substrate, bi-bi ordered mechanism | Myxozyma melibiosi | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| myo-inositol + NAD+ | Myxozyma melibiosi | - |
scyllo-inosose + NADH | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Myxozyma melibiosi | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Myxozyma melibiosi |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Myxozyma melibiosi | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.68 | - |
- |
Myxozyma melibiosi |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| myo-inositol + NAD+ | - |
Myxozyma melibiosi | scyllo-inosose + NADH | - |
r | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | can not be replaced by NADP+ | Myxozyma melibiosi | |
| NADH | - |
Myxozyma melibiosi | |
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Release 2023.1 (January 2023)
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