Literature summary for 1.1.1.169 extracted from

Ciulli, A.; Abell, C.
Biophysical tools to monitor enzyme-ligand interactions of enzymes involved in vitamin biosynthesis (2005), Biochem. Soc. Trans., 33, 767-771.

Search for more literature for 1.1.1.169

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	ligand bindig modelling for inhibitor design	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ketopantoate + NADPH	Escherichia coli	the enzyme is involved in pantothenate, i.e. vitamin B5, biosynthesis, which is a precursor for CoA	pantoate + NADP+	-	r

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	gene panE	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ketopantoate + NADPH	the enzyme is involved in pantothenate, i.e. vitamin B5, biosynthesis, which is a precursor for CoA	Escherichia coli	pantoate + NADP+	-	r
ketopantoate + NADPH	the 4-proS hydrogen is transferred from NADPH to ketopantoate to form pantoate and NADP+, ligand binding analysis by NMR spectroscopy	Escherichia coli	pantoate + NADP+	-	r

Synonyms

Synonyms	Comment	Organism
ketopantoate reductase	-	Escherichia coli
KPR	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	cofactor binding structure and thermodynamics	Escherichia coli
NADPH	cofactor binding structure and thermodynamics	Escherichia coli

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Release 2023.1 (January 2023)