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Literature summary for 1.1.1.159 extracted from

  • Hylemon, P.B.; Sherrod, J.A.
    Multiple forms of 7-alpha-hydroxysteroid dehydrogenase in selected strains of Bacteroides fragilis (1975), J. Bacteriol., 122, 418-424.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptoethanol
-
Bacteroides fragilis
EDTA
-
Bacteroides fragilis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activation Bacteroides fragilis
MnCl2 activation Bacteroides fragilis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
NAD+-specific form, gel filtration Bacteroides fragilis
127000
-
NADP+-dependent form, gel filtration Bacteroides fragilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bile acids + NAD(P)+ Bacteroides fragilis serve as energy sources in absence of glucose ?
-
?

Organism

Organism UniProt Comment Textmining
Bacteroides fragilis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Bacteroides fragilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bile acids + NAD(P)+ serve as energy sources in absence of glucose Bacteroides fragilis ?
-
?
chenodeoxycholic acid + NAD(P)+ preferred substrate with NAD+ as coenzyme Bacteroides fragilis 3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NAD(P)H
-
?
chenodeoxycholic acid + NAD(P)+ i.e. 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid Bacteroides fragilis 3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NAD(P)H
-
?
cholic acid + NAD(P)+ preferred substrate with NADP+ as coenzyme Bacteroides fragilis 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
-
?
cholic acid + NAD(P)+ i.e. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate Bacteroides fragilis 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
-
?
glycochenodeoxycholic acid + NAD(P)+
-
Bacteroides fragilis N-[3alpha-hydroxy-7,24-dioxocholan-24-yl]glycine + NAD(P)H
-
?
glycocholic acid + NAD+ i.e. N-[3alpha,7alpha,12alpha-trihydroxy-24-oxocholan-24-yl]glycine Bacteroides fragilis N-[3alpha,12alpha-dihydroxy-7,24-dioxo-5beta-cholan-24-yl]glycine + NADH
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
65
-
inactivation of NADP+-dependent form, NAD+-dependent form stable Bacteroides fragilis
75
-
30 min, presence of substrates, NAD+-dependent form stable Bacteroides fragilis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5 9 oxidation of 7alpha-hydroxy group Bacteroides fragilis

Cofactor

Cofactor Comment Organism Structure
NAD+ one enzyme form specific for NAD+, other form specific for NADP+ Bacteroides fragilis
NADP+ one enzyme form specific for NADP+, other form specific for NAD+ Bacteroides fragilis