Any feedback?
Literature summary for 1.1.1.159 extracted from
- Bile induction of 7alpha- and 7beta-hydroxysteroid dehydrogenases in Clostridium absonum (1981), Biochim. Biophys. Acta, 665, 262-269.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0065 | - |
chenodeoxycholic acid | - |
Clostridium sardiniense |  |
| 0.09 | - |
cholic acid | - |
Clostridium sardiniense | |
| 0.42 | - |
NADP+ | - |
Clostridium sardiniense | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Clostridium sardiniense | bile acid-induction, e.g. deoxycholate and chenodeoxycholate, is necessary for measurable activity, induction is inhibited by ursodeoxycholate | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium sardiniense | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity in crude extracts of different strains | Clostridium sardiniense |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chenodeoxycholic acid + NAD+ | - |
Clostridium sardiniense | 3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADH + H+ | - |
r | |
| cholic acid + NAD+ | - |
Clostridium sardiniense | 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate + NADH + H+ | - |
r | |
| cholic acid + NADP+ | - |
Clostridium sardiniense | 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate + NADPH + H+ | - |
r | |
| additional information | bile acid-induction, e.g. deoxycholate and chenodeoxycholate, is necessary for measurable activity, induction is inhibited by ursodeoxycholate | Clostridium sardiniense | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.5 | 10.5 | - |
Clostridium sardiniense |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 10.5 | - |
Clostridium sardiniense |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
