Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.153 extracted from

  • Tobin, J.E.; Cui, J.; Wilk, J.B.; Latourelle, J.C.; Laramie, J.M.; McKee, A.C.; Guttman, M.; Karamohamed, S.; DeStefano, A.L.; Myers, R.H.
    Sepiapterin reductase expression is increased in Parkinsons disease brain tissue (2007), Brain Res., 1139, 42-47.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
chromosomal location 2p14-2p12, RT-PCR expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information a single nucleotide polymorphism around the SPR gene is involved in development of Parkonson's disease Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH Homo sapiens
-
tetrahydrobiopterin + NADP+ the cofactor for aromatic amino acid hydrolases in the biosynthesis of aromatc amino acids and dopamine r
additional information Homo sapiens the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis, sepiapterin reductase expression is increased in Parkinsons disease brain tissue ?
-
?
sepiapterin + NADPH + H+ Homo sapiens
-
7,8-dihydrobiopterin + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain sepiapterin reductase expression is increased in Parkinsons disease brain tissue Homo sapiens
-
cerebellum post-mortem semi-quantitative expression analysis in brain of control individuals and Parkinson disease patients, SPR expression is increased in Parkinson patients, but not in the other genes involved in the tetrahydrobiopterin biosynthesis, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
-
Homo sapiens tetrahydrobiopterin + NADP+
-
r
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
-
Homo sapiens tetrahydrobiopterin + NADP+ the cofactor for aromatic amino acid hydrolases in the biosynthesis of aromatc amino acids and dopamine r
additional information the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis, sepiapterin reductase expression is increased in Parkinsons disease brain tissue Homo sapiens ?
-
?
sepiapterin + NADPH + H+
-
Homo sapiens 7,8-dihydrobiopterin + NADP+
-
r